TOM1 explained

Target of Myb protein 1 is a protein that in humans is encoded by the TOM1 gene.^{[1] [2] [3]}

The specific function of this gene has not yet been determined, yet it may involve the translocation of growth factor receptor complexes to the lysosome for degradation. This gene is localized to 22q13.1, with HMOX1 and MCM5 distally and HMG2L1 proximally positioned.^[3]

Interactions

TOM1 has been shown to interact with TOLLIP^[4] and ZFYVE16.^[5]

Further reading

• Dunham I, Shimizu N, Roe BA, etal . The DNA sequence of human chromosome 22. . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Misra S, Beach BM, Hurley JH . Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes. . Biochemistry . 39 . 37 . 11282–90 . 2000 . 10985773 . 10.1021/bi0013546 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Yamakami M, Yoshimori T, Yokosawa H . Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin. . J. Biol. Chem. . 278 . 52 . 52865–72 . 2004 . 14563850 . 10.1074/jbc.M306740200 . free .
• Seet LF, Liu N, Hanson BJ, Hong W . Endofin recruits TOM1 to endosomes. . J. Biol. Chem. . 279 . 6 . 4670–9 . 2004 . 14613930 . 10.1074/jbc.M311228200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Collins JE, Wright CL, Edwards CA, etal . A genome annotation-driven approach to cloning the human ORFeome. . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . free .
• Seet LF, Hong W . Endofin recruits clathrin to early endosomes via TOM1. . J. Cell Sci. . 118 . Pt 3 . 575–87 . 2005 . 15657082 . 10.1242/jcs.01628 . free .
• Schmid EM, Ford MG, Burtey A, etal . Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. . PLOS Biol. . 4 . 9 . e262 . 2007 . 16903783 . 10.1371/journal.pbio.0040262 . 1540706 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .

Notes and References

1. Seroussi E, Kedra D, Kost-Alimova M, Sandberg-Nordqvist AC, Fransson I, Jacobs JF, Fu Y, Pan HQ, Roe BA, Imreh S, Dumanski JP . TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM . Genomics . 57 . 3 . 380–8 . Aug 1999 . 10329004 . 10.1006/geno.1998.5739 .
2. Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K . Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes . J Biol Chem . 279 . 23 . 24435–43 . May 2004 . 15047686 . 10.1074/jbc.M400059200 . free .
3. Web site: Entrez Gene: TOM1 target of myb1 (chicken).
4. Yamakami . Megumi . Yoshimori Tamotsu . Yokosawa Hideyoshi . Dec 2003 . Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin . J. Biol. Chem. . 278 . 52 . 52865–72 . 0021-9258. 14563850 . 10.1074/jbc.M306740200 . free .
5. Seet . Li-Fong . Liu Ningsheng . Hanson Brendon J . Hong Wanjin . Feb 2004 . Endofin recruits TOM1 to endosomes . J. Biol. Chem. . 279 . 6 . 4670–9 . 0021-9258. 14613930 . 10.1074/jbc.M311228200 . free .