TOB2 explained

Protein Tob2 (transducer of ERBB2, 2) is a protein that in humans is encoded by the TOB2 gene.^{[1] [2] [3] [4]}

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM]

Interactions

TOB2 has been shown to interact with CNOT7.

Further reading

• Hirosawa M, Nagase T, Murahashi Y, etal . Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping . DNA Res. . 8 . 1 . 1–9 . 2001 . 11258795 . 10.1093/dnares/8.1.1 . free .
• Suzuki T, Matsuda S, Tsuzuku JK, etal . A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob . Genes Cells . 6 . 2 . 131–8 . 2001 . 11260258 . 10.1046/j.1365-2443.2001.00406.x . free .
• Yoshida Y, Hosoda E, Nakamura T, Yamamoto T . Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex . Jpn. J. Cancer Res. . 92 . 6 . 592–6 . 2001 . 11429045 . 10.1111/j.1349-7006.2001.tb01135.x . 5926753 .
• Sasajima H, Nakagawa K, Yokosawa H . Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system . Eur. J. Biochem. . 269 . 14 . 3596–604 . 2002 . 12135500 . 10.1046/j.1432-1033.2002.03052.x .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Collins JE, Wright CL, Edwards CA, etal . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T . Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases . Oncogene . 18 . 52 . 7432–41 . Jan 2000 . 10602502 . 10.1038/sj.onc.1203193 . free .
2. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP. The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . Dec 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . etal. free .
3. Web site: Entrez Gene: TOB2 transducer of ERBB2, 2.
4. Web site: TOB2 transducer of ERBB2, 2 [Homo sapiens (human)] - Gene - NCBI ]. 2023-09-24 . www.ncbi.nlm.nih.gov.