TNS1 explained

Tensin-1 is a protein that in humans is encoded by the TNS1 gene.^[1]

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.^[1]

External links

• TNS1 Info with links in the Cell Migration Gateway

Further reading

• Jankowski SA, Gumucio DL . Genes for tensin, villin and desmin are linked on mouse chromosome 1. . Mamm. Genome . 6 . 10 . 744–5 . 1996 . 8563175 . 10.1007/BF00354299 . 2027.42/47016 . 22316923 . free .
• Salgia R, Pisick E, Sattler M, etal . p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene. . J. Biol. Chem. . 271 . 41 . 25198–203 . 1996 . 8810278 . 10.1074/jbc.271.41.25198 . free .
• Dias Neto E, Correa RG, Verjovski-Almeida S, etal . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . 2000PNAS...97.3491D . free .
• Katz BZ, Zohar M, Teramoto H, etal . Tensin can induce JNK and p38 activation. . Biochem. Biophys. Res. Commun. . 272 . 3 . 717–20 . 2000 . 10860821 . 10.1006/bbrc.2000.2853 .
• Chen H, Ishii A, Wong WK, etal . Molecular characterization of human tensin. . Biochem. J. . 351 Pt 2 . 2. 403–11 . 2001 . 11023826 . 10.1042/0264-6021:3510403. 1221376 .
• Benzing T, Gerke P, Höpker K, etal . Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 17 . 9784–9 . 2001 . 11493697 . 10.1073/pnas.171269898 . 55530 . 2001PNAS...98.9784B . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Yamashita M, Horikoshi S, Asanuma K, etal . Tensin is potentially involved in extracellular matrix production in mesangial cells. . Histochem. Cell Biol. . 121 . 3 . 245–54 . 2004 . 14991332 . 10.1007/s00418-004-0626-8 . 5634607 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Eto M, Kirkbride J, Elliott E, etal . Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions. . J. Biol. Chem. . 282 . 24 . 17806–15 . 2007 . 17435217 . 10.1074/jbc.M700944200 . free .

Notes and References

1. Web site: Entrez Gene: TNS1 tensin 1.