TNPO2 explained

Transportin-2 is a protein that in humans is encoded by the TNPO2 gene.^{[1] [2] [3]}

Interactions

TNPO2 has been shown to interact with NXF1, NUP98^[4] and Ran (biology).^[2]

Further reading

• Gallouzi IE, Steitz JA . Delineation of mRNA export pathways by the use of cell-permeable peptides . Science . 294 . 5548 . 1895–901 . November 2001 . 11729309 . 10.1126/science.1064693 . 2001Sci...294.1895G . 43726887 .
• Blanc V, Kennedy S, Davidson NO . A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling . The Journal of Biological Chemistry . 278 . 42 . 41198–204 . October 2003 . 12896982 . 10.1074/jbc.M302951200 . free .
• Güttinger S, Mühlhäusser P, Koller-Eichhorn R, Brennecke J, Kutay U . Transportin2 functions as importin and mediates nuclear import of HuR . Proceedings of the National Academy of Sciences of the United States of America . 101 . 9 . 2918–23 . March 2004 . 14981248 . 365720 . 10.1073/pnas.0400342101 . 2004PNAS..101.2918G . free .
• Rebane A, Aab A, Steitz JA . Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR . RNA . 10 . 4 . 590–9 . April 2004 . 15037768 . 1370549 . 10.1261/rna.5224304 .
• Lee BJ, Cansizoglu AE, Süel KE, Louis TH, Zhang Z, Chook YM . Rules for nuclear localization sequence recognition by karyopherin beta 2 . Cell . 126 . 3 . 543–58 . August 2006 . 16901787 . 3442361 . 10.1016/j.cell.2006.05.049 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Siomi MC, Eder PS, Kataoka N, Wan L, Liu Q, Dreyfuss G . Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins . The Journal of Cell Biology . 138 . 6 . 1181–92 . September 1997 . 9298975 . 2132560 . 10.1083/jcb.138.6.1181 .
2. Shamsher MK, Ploski J, Radu A . Karyopherin beta 2B participates in mRNA export from the nucleus . Proceedings of the National Academy of Sciences of the United States of America . 99 . 22 . 14195–9 . October 2002 . 12384575 . 137860 . 10.1073/pnas.212518199 . 2002PNAS...9914195S . free .
3. Web site: Entrez Gene: TNPO2 transportin 2 (importin 3, karyopherin beta 2b).
4. Fontoura BM, Blobel G, Yaseen NR . The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import . The Journal of Biological Chemistry . 275 . 40 . 31289–96 . October 2000 . 10875935 . 10.1074/jbc.M004651200 . free .