TNP2 explained

Nuclear transition protein 2 is a protein that in humans is encoded by the TNP2 gene.^{[1] [2] [3]}

Further reading

• Schlüter G, Kremling H, Engel W . The gene for human transition protein 2: nucleotide sequence, assignment to the protamine gene cluster, and evidence for its low expression. . Genomics . 14 . 2 . 377–83 . 1992 . 1385303 . 10.1016/S0888-7543(05)80229-0 .
• Kundu TK, Rao MR . DNA condensation by the rat spermatidal protein TP2 shows GC-rich sequence preference and is zinc dependent. . Biochemistry . 34 . 15 . 5143–50 . 1995 . 7711033 . 10.1021/bi00015a027 .
• Nelson JE, Krawetz SA . Characterization of a human locus in transition. . J. Biol. Chem. . 269 . 49 . 31067–73 . 1995 . 10.1016/S0021-9258(18)47391-7 . 7983046 . free .
• Nelson JE, Krawetz SA . Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the P1-->P2-->TP2 locus. . J. Biol. Chem. . 268 . 4 . 2932–6 . 1993 . 10.1016/S0021-9258(18)53863-1 . 8428967 . free .
• Kundu TK, Rao MR . Zinc dependent recognition of a human CpG island sequence by the mammalian spermatidal protein TP2. . Biochemistry . 35 . 49 . 15626–32 . 1997 . 8961924 . 10.1021/bi961271i .
• Steger K . Expression of mRNA and protein of nucleoproteins during human spermiogenesis . Mol. Hum. Reprod. . 4 . 10 . 939–45 . 1999 . 9809674 . 10.1093/molehr/4.10.939 . vanc. Klonisch T . Gavenis K . 3 . Drabent . B . Doenecke . D . Bergmann . M .
• Wyckoff GJ, Wang W, Wu CI . Rapid evolution of male reproductive genes in the descent of man . Nature . 403 . 6767 . 304–9 . 2000 . 10659848 . 10.1038/35002070 . 2000Natur.403..304W . 3136139 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Wykes SM, Krawetz SA . The structural organization of sperm chromatin . J. Biol. Chem. . 278 . 32 . 29471–7 . 2003 . 12775710 . 10.1074/jbc.M304545200 . free .
• Miyagawa Y . Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations . J. Androl. . 26 . 6 . 779–86 . 2006 . 16291974 . 10.2164/jandrol.05069 . vanc. Nishimura H . Tsujimura A . 3 . Matsuoka . Y . Matsumiya . K . Okuyama . A . Nishimune . Y . Tanaka . H . free .
• Jedrzejczak P . Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men . Arch. Androl. . 53 . 4 . 199–205 . 2007 . 17852044 . 10.1080/01485010701426430 . vanc. Kempisty B . Bryja A . 3 . Mostowska . M. . Depa-Martynow . Magdalena . Pawelczyk . Leszek . Jagodzinski . Pawel Piotr . 21999596 .

Notes and References

1. Engel W, Keime S, Kremling H, Hameister H, Schluter G . The genes for protamine 1 and 2 (PRM1 and PRM2) and transition protein 2 (TNP2) are closely linked in the mammalian genome . Cytogenet Cell Genet . 61 . 2 . 158–9 . Nov 1992 . 1395729 . 10.1159/000133397 .
2. Baskaran R, Rao MR . Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1 . J Biol Chem . 265 . 34 . 21039–47 . Jan 1991 . 10.1016/S0021-9258(17)45324-5 . 2250010 . free .
3. Web site: Entrez Gene: TNP2 transition protein 2 (during histone to protamine replacement).