TNP1 explained

Spermatid nuclear transition protein 1 is a protein that in humans is encoded by the TNP1 gene.^{[1] [2]}

Further reading

• Meistrich ML, Mohapatra B, Shirley CR, Zhao M . Roles of transition nuclear proteins in spermiogenesis. . Chromosoma . 111 . 8 . 483–8 . 2004 . 12743712 . 10.1007/s00412-002-0227-z . 28866607 .
• Chirat F, Martinage A, Briand G, etal . Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants. . Eur. J. Biochem. . 198 . 1 . 13–20 . 1991 . 2040274 . 10.1111/j.1432-1033.1991.tb15980.x . free .
• Baskaran R, Rao MR . Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1. . J. Biol. Chem. . 265 . 34 . 21039–47 . 1991 . 10.1016/S0021-9258(17)45324-5 . 2250010 . free .
• Kleene KC, Borzorgzadeh A, Flynn JF, etal . Nucleotide sequence of a cDNA clone encoding mouse transition protein 1. . Biochim. Biophys. Acta . 950 . 2 . 215–20 . 1988 . 3382664 . 10.1016/0167-4781(88)90013-9.
• Luerssen H, Hoyer-Fender S, Engel W . The nucleotide sequence of human transition protein 1 cDNA. . Nucleic Acids Res. . 16 . 15 . 7723 . 1988 . 3412903 . 10.1093/nar/16.15.7723. 338445 .
• Akama K, Kojima S, Nakano M, etal . The amino acid sequence and phosphorylation sites of a boar transition protein 1. . Biochem. Mol. Biol. Int. . 32 . 2 . 349–57 . 1994 . 8019440 .
• Steger K, Klonisch T, Gavenis K, etal . Expression of mRNA and protein of nucleoproteins during human spermiogenesis. . Mol. Hum. Reprod. . 4 . 10 . 939–45 . 1999 . 9809674 . 10.1093/molehr/4.10.939 .
• Yu YE, Zhang Y, Unni E, etal . Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 9 . 4683–8 . 2000 . 10781074 . 10.1073/pnas.97.9.4683. 18293 . 2000PNAS...97.4683Y . free .
• Siffroi JP, Alfonsi MF, Dadoune JP . Electron microscopic in situ hybridization study of simultaneous expression of TNP1 and PRM1 genes in human spermatids. . Italian Journal of Anatomy and Embryology = Archivio Italiano di Anatomia ed Embriologia . 103 . 4 Suppl 1 . 65–74 . 2001 . 11315969 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Miyagawa Y, Nishimura H, Tsujimura A, etal . Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations. . J. Androl. . 26 . 6 . 779–86 . 2006 . 16291974 . 10.2164/jandrol.05069 . free .
• Jedrzejczak P, Kempisty B, Bryja A, etal . Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men. . Arch. Androl. . 53 . 4 . 199–205 . 2007 . 17852044 . 10.1080/01485010701426430 . 21999596 .

Notes and References

1. Luerssen H, Mattei MG, Schroter M, Grzeschik KH, Adham IM, Engel W . Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2 . Genomics . 8 . 2 . 324–30 . Jan 1991 . 2249851 . 10.1016/0888-7543(90)90289-7 .
2. Web site: Entrez Gene: TNP1 transition protein 1 (during histone to protamine replacement).