Troponin C, skeletal muscle explained

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene.^{[1] [2]}

Troponin (Tn), is a key protein complex in the regulation of striated muscle contraction, composed of three subunits. The TnI subunit inhibits actomyosin ATPase, the TnT subunit binds tropomyosin and TnC, while the TnC subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin thin filaments. The protein encoded by the TNNC2 gene is the TnC subunit.^[3]

Further reading

• Romero-Herrera AE, Castillo O, Lehmann H . Human skeletal muscle proteins. The primary structure of troponin C. . J. Mol. Evol. . 8 . 3 . 251–70 . 1977 . 978749 . 10.1007/bf01730999. 12057790 .
• Tomasselli AG, Hui JO, Adams L, etal . Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus. . J. Biol. Chem. . 266 . 22 . 14548–53 . 1991 . 10.1016/S0021-9258(18)98721-1 . 1907279 . free .
• Gahlmann R, Wade R, Gunning P, Kedes L . Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts. . J. Mol. Biol. . 201 . 2 . 379–91 . 1988 . 3166492 . 10.1016/0022-2836(88)90145-3 .
• Prentice H, Kloner RA, Prigozy T, etal . Tissue restricted gene expression assayed by direct DNA injection into cardiac and skeletal muscle. . J. Mol. Cell. Cardiol. . 26 . 10 . 1393–401 . 1995 . 7869399 . 10.1006/jmcc.1994.1157 .
• Tiso N, Rampoldi L, Pallavicini A, etal . Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast. . Biochem. Biophys. Res. Commun. . 230 . 2 . 347–50 . 1997 . 9016781 . 10.1006/bbrc.1996.5958 . 11577/2466889 . free .
• Townsend PJ, Yacoub MH, Barton PJ . Assignment of the human fast skeletal muscle troponin C gene (TNNC2) between D20S721 and GCT10F11 on chromosome 20 by somatic cell hybrid analysis. . Ann. Hum. Genet. . 61 . Pt 5 . 457–9 . 1998 . 9459007 . 10.1046/j.1469-1809.1997.6150457.x . 1450195 . free .
• Vassylyev DG, Takeda S, Wakatsuki S, etal . Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 9 . 4847–52 . 1998 . 9560191 . 10.1073/pnas.95.9.4847 . 20176 . free .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Gahlmann R, Kedes L . Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene . J Biol Chem . 265 . 21 . 12520–8 . Aug 1990 . 10.1016/S0021-9258(19)38376-0 . 2373703 . free .
2. Web site: Entrez Gene: TNNC2 troponin C type 2 (fast).
3. Web site: Entrez Gene: TNNC2 troponin C type 2 (fast).