Tankyrase 2 Explained

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.^[1]

Interactions

TNKS2 has been shown to interact with GRB14,^[2] TERF1^{[3] [4] [5]} and Cystinyl aminopeptidase.^{[4] [5] [6]}

Further reading

• Monz D, Munnia A, Comtesse N, etal . Novel tankyrase-related gene detected with meningioma-specific sera. . Clin. Cancer Res. . 7 . 1 . 113–9 . 2001 . 11205898 .
• Lyons RJ, Deane R, Lynch DK, etal . Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14. . J. Biol. Chem. . 276 . 20 . 17172–80 . 2001 . 11278563 . 10.1074/jbc.M009756200 . free .
• Kuimov AN, Kuprash DV, Petrov VN, etal . Cloning and characterization of TNKL, a member of tankyrase gene family. . Genes Immun. . 2 . 1 . 52–5 . 2001 . 11294570 . 10.1038/sj.gene.6363722 . 21519595 .
• Kaminker PG, Kim SH, Taylor RD, etal . TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. . J. Biol. Chem. . 276 . 38 . 35891–9 . 2001 . 11454873 . 10.1074/jbc.M105968200 . free .
• Cook BD, Dynek JN, Chang W, etal . Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. . Mol. Cell. Biol. . 22 . 1 . 332–42 . 2002 . 11739745 . 10.1128/MCB.22.1.332-342.2002 . 134233 .
• Sbodio JI, Lodish HF, Chi NW . Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). . Biochem. J. . 361 . Pt 3 . 451–9 . 2002 . 11802774 . 10.1042/0264-6021:3610451 . 1222327 .
• Seimiya H, Smith S . The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). . J. Biol. Chem. . 277 . 16 . 14116–26 . 2002 . 11854288 . 10.1074/jbc.M112266200 . free .
• Sbodio JI, Chi NW . Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner. . J. Biol. Chem. . 277 . 35 . 31887–92 . 2002 . 12080061 . 10.1074/jbc.M203916200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Deloukas P, Earthrowl ME, Grafham DV, etal . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . free .
• Deng Z, Atanasiu C, Zhao K, etal . Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1. . J. Virol. . 79 . 8 . 4640–50 . 2005 . 15795250 . 10.1128/JVI.79.8.4640-4650.2005 . 1069541 .
• Sidorova N, Zavalishina L, Kurchashova S, etal . Immunohistochemical detection of tankyrase 2 in human breast tumors and normal renal tissue. . Cell Tissue Res. . 323 . 1 . 137–45 . 2006 . 16151859 . 10.1007/s00441-005-0053-8 . 21992320 .

Notes and References

1. Web site: Entrez Gene: TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2.
2. Lyons . R J . Deane R . Lynch D K . Ye Z S . Sanderson G M . Eyre H J . Sutherland G R . Daly R J . May 2001 . Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14 . J. Biol. Chem. . 276 . 20 . 17172–80 . United States. 0021-9258. 11278563 . 10.1074/jbc.M009756200 . free .
3. 10.1128/MCB.22.1.332-342.2002 . Cook . Brandoch D . Dynek Jasmin N . Chang William . Shostak Grigoriy . Smith Susan . January 2002 . Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres . Mol. Cell. Biol. . 22 . 1 . 332–42 . United States. 0270-7306. 11739745 . 134233 .
4. Chi . N W . Lodish H F . Dec 2000 . Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles . J. Biol. Chem. . 275 . 49 . 38437–44 . UNITED STATES. 0021-9258. 10988299 . 10.1074/jbc.M007635200 . free .
5. 10.1042/0264-6021:3610451 . Sbodio . Juan I . Lodish Harvey F . Chi Nai-Wen . February 2002 . Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase) . Biochem. J. . 361 . Pt 3 . 451–9 . England. 0264-6021. 11802774 . 1222327 .
6. Sbodio . Juan I . Chi Nai-Wen . August 2002 . Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner . J. Biol. Chem. . 277 . 35 . 31887–92 . United States. 0021-9258. 12080061 . 10.1074/jbc.M203916200 . free .