TNIP2 explained

TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene.^{[1] [2] [3]} TNIP2 contains multiple amino acid sites that are phosphorylated and ubiquitinated.^[4]

Further reading

• Heyninck K . The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN . J. Cell Biol. . 145 . 7 . 1471–82 . 1999 . 10385526 . 10.1083/jcb.145.7.1471 . 2133159 . vanc. De Valck D . Vanden Berghe W . 3 . Van Criekinge . W . Contreras . R . Fiers . W . Haegeman . G . Beyaert . R . 1854/LU-113881.
• Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R . Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions . FEBS Lett. . 498 . 1 . 93–7 . 2001 . 11389905 . 10.1016/S0014-5793(01)02504-2 . 32414520 .
• Wu WS, Xu ZX, Chang KS . The promyelocytic leukemia protein represses A20-mediated transcription . J. Biol. Chem. . 277 . 35 . 31734–9 . 2002 . 12080044 . 10.1074/jbc.M201648200 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Liu WK, Chien CY, Chou CK, Su JY . An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation . J. Biomed. Sci. . 10 . 2 . 242–52 . 2003 . 12595760 . 10.1159/000068708 . 202644741 .
• Hughes DP, Marron MB, Brindle NP . The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2 . Circ. Res. . 92 . 6 . 630–6 . 2003 . 12609966 . 10.1161/01.RES.0000063422.38690.DC . free . 2381/866 . free .
• Chien CY, Liu WK, Chou CK, Su JY . The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation . FEBS Lett. . 543 . 1–3 . 55–60 . 2003 . 12753905 . 10.1016/S0014-5793(03)00401-0 . 31400521 . free .
• Liu WK . The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis . Biochem. J. . 378 . Pt 3 . 867–76 . 2004 . 14653779 . 10.1042/BJ20031736 . 1224013 . vanc. Yen PF . Chien CY . 3 . Fann . Ming-Ji . Su . Jin-Yuan . Chou . Chen-Kung .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Bouwmeester T . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . vanc. Bauch A . Ruffner H . 3 . Angrand . Pierre-Olivier . Bergamini . Giovanna . Croughton . Karen . Cruciat . Cristina . Eberhard . Dirk . Gagneur . Julien . 11683986 .
• Lang V . ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability . Mol. Cell. Biol. . 24 . 12 . 5235–48 . 2004 . 15169888 . 10.1128/MCB.24.12.5235-5248.2004 . 419892 . vanc. Symons A . Watton SJ . 3 . Janzen . J. . Soneji . Y. . Beinke . S. . Howell . S. . Ley . S. C. .
• Li CC, Chou CK, Wang MH, Tsai TF . Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice . Biochem. Biophys. Res. Commun. . 342 . 1 . 300–9 . 2006 . 16480954 . 10.1016/j.bbrc.2006.01.114 .
• Greenberg H . Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo . Biochem. Biophys. Res. Commun. . 343 . 2 . 591–6 . 2006 . 16554025 . 10.1016/j.bbrc.2006.03.015 . vanc. Ye X . Wilson D . 3 . Htoo . Aung K. . Hendersen . Todd . Liu . Shu Fang .
• Liu Y . Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells . J. Radiat. Res. . 48 . 1 . 13–20 . 2007 . 17038805 . 10.1269/jrr.0615 . vanc. Nakahara T . Miyakoshi J . 3 . Hu . Dong-Liang . Nakane . Akio . Abe . Yoshinao . 2007JRadR..48...13L . free .

Notes and References

1. Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R . Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2 . J Biol Chem . 276 . 32 . 30216–23 . Aug 2001 . 11390377 . 10.1074/jbc.M100048200 . free .
2. Tadros A, Hughes DP, Dunmore BJ, Brindle NP . ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1 . Blood . 102 . 13 . 4407–9 . Dec 2003 . 12933576 . 10.1182/blood-2003-05-1602 . free .
3. Web site: Entrez Gene: TNIP2 TNFAIP3 interacting protein 2.
4. Web site: TNIP2 (human). 2020-10-31. www.phosphosite.org.