TNFSF12-TNFSF13 explained

Tumor necrosis factor (ligand) superfamily, member 12-member 13, also known as TNFSF12-TNFSF13, is a human gene.^[1]

This gene belongs to the tumor necrosis factor superfamily (TNFSF). It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of the family member 12 fused to the C-terminal domain of the family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of the family member 13 at the cell surface. It stimulates cycling in T-lymphoma and B-lymphoma cell lines. The mRNA transcript is expressed and translated in primary T cells and monocytes.

Further reading

• Hahne M . APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth . J. Exp. Med. . 188 . 6 . 1185–90 . 1998 . 9743536 . 10.1084/jem.188.6.1185 . 2212534 . vanc. Kataoka T . Schröter M . 3 . Hofmann . K . Irmler . M . Bodmer . JL . Schneider . P . Bornand . T . Holler . N .
• Kelly K . APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death . Cancer Res. . 60 . 4 . 1021–7 . 2000 . 10706119 . vanc. Manos E . Jensen G . 3 . Nadauld . L . Jones . DA .
• Wu Y . Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS . J. Biol. Chem. . 275 . 45 . 35478–85 . 2001 . 10956646 . 10.1074/jbc.M005224200 . vanc. Bressette D . Carrell JA . 3 . Kaufman . T . Feng . P . Taylor . K . Gan . Y . Cho . YH . Garcia . AD . free .
• Yu G . APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity . Nat. Immunol. . 1 . 3 . 252–6 . 2001 . 10973284 . 10.1038/79802 . vanc. Boone T . Delaney J . 3 . Hawkins . Nessa . Kelley . Michael . Ramakrishnan . Meena . McCabe . Susan . Qiu . Wan-Rong . Kornuc . Masayo . 6799584 .
• López-Fraga M, Fernández R, Albar JP, Hahne M . Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase . EMBO Rep. . 2 . 10 . 945–51 . 2002 . 11571266 . 10.1093/embo-reports/kve198 . 1084076 .
• Roschke V . BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases . J. Immunol. . 169 . 8 . 4314–21 . 2002 . 12370363 . 10.4049/jimmunol.169.8.4314. vanc. Sosnovtseva S . Ward CD . 3 . Hong . JS . Smith . R . Albert . V . Stohl . W . Baker . KP . Ullrich . S . free .
• Pradet-Balade B . An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK–APRIL fusion protein . EMBO J. . 21 . 21 . 5711–20 . 2002 . 12411489 . 10.1093/emboj/cdf565 . 131062 . vanc. Medema JP . López-Fraga M . 3 . Lozano . JC . Kolfschoten . GM . Picard . A . Martínez-a . C . Garcia-Sanz . JA . Hahne . M .
• Hendriks J . Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation . Cell Death Differ. . 12 . 6 . 637–48 . 2005 . 15846369 . 10.1038/sj.cdd.4401647 . vanc. Planelles L . de Jong-Odding J . 3 . Hardenberg . G . Pals . S T . Hahne . M . Spaargaren . M . Medema . J P . free .

Notes and References

1. Web site: Entrez Gene: TNFSF12-TNFSF13 tumor necrosis factor (ligand) superfamily, member 12-member 13.