TNFRSF19 explained

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.^[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TNF receptor associated factor (TRAF) family members, and to activate c-Jun N-terminal kinases (JNK) signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

See also

• Mitogen-activated protein kinase for JNK signaling pathway description

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, etal . Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening . Genomics . 23 . 1 . 42–50 . 1995 . 7829101 . 10.1006/geno.1994.1457 .
• Kojima T, Morikawa Y, Copeland NG, etal . TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles . J. Biol. Chem. . 275 . 27 . 20742–7 . 2000 . 10764796 . 10.1074/jbc.M002691200 . free .
• Eby MT, Jasmin A, Kumar A, etal . TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death . J. Biol. Chem. . 275 . 20 . 15336–42 . 2000 . 10809768 . 10.1074/jbc.275.20.15336 . free .
• Naito A, Yoshida H, Nishioka E, etal . TRAF6-deficient mice display hypohidrotic ectodermal dysplasia . Proc. Natl. Acad. Sci. U.S.A. . 99 . 13 . 8766–71 . 2002 . 12060722 . 10.1073/pnas.132636999 . 124373 . free . 2002PNAS...99.8766N .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Park JB, Yiu G, Kaneko S, etal . A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors . Neuron . 45 . 3 . 345–51 . 2005 . 15694321 . 10.1016/j.neuron.2004.12.040 . free .
• Shao Z, Browning JL, Lee X, etal . TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration . Neuron . 45 . 3 . 353–9 . 2005 . 15694322 . 10.1016/j.neuron.2004.12.050 . free .
• Spanjaard RA, Whren KM, Graves C, Bhawan J . Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target . Int. J. Cancer . 120 . 6 . 1304–10 . 2007 . 17187358 . 10.1002/ijc.22367 . free .
• Satoh J, Tabunoki H, Yamamura T, etal . TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions . Neuropathol. Appl. Neurobiol. . 33 . 1 . 99–107 . 2007 . 17239012 . 10.1111/j.1365-2990.2006.00787.x . 36762956 .

Notes and References

1. Web site: Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19.