TNFAIP8 explained

Tumor necrosis factor, alpha-induced protein 8 is a protein that in humans is encoded by the TNFAIP8 gene.^{[1] [2] [3]} It is preferentially expressed in human immune cell types.^[4]

Further reading

• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Suzuki Y, Yamashita R, Shirota M, etal . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 .
• Kumar D, Gokhale P, Broustas C, etal . Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. . Oncogene . 23 . 2 . 612–6 . 2004 . 14724590 . 10.1038/sj.onc.1207123 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H . Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes . Blood . 93 . 10 . 3418–31 . Jun 1999 . 10233894 . 10.1182/blood.V93.10.3418.410k23_3418_3431.
2. Kumar D, Whiteside TL, Kasid U . Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin- 1beta-converting enzyme-inhibitory protein . J Biol Chem . 275 . 4 . 2973–8 . Feb 2000 . 10644768 . 10.1074/jbc.275.4.2973 . free .
3. Web site: Entrez Gene: TNFAIP8 tumor necrosis factor, alpha-induced protein 8.
4. Li T, Wang W, etal . Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism . Molecular Immunology . May 2018. 99 . 154–162. 29787979. 10.1016/j.molimm.2018.05.007. 5995464.