TNFAIP1 explained

BTB/POZ domain-containing protein TNFAIP1 is a protein that in humans is encoded by the TNFAIP1 gene.^{[1] [2] [3]}

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner.^[4]

Further reading

• Wolf FW, Marks RM, Sarma V, etal . Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene. . J. Biol. Chem. . 267 . 2 . 1317–26 . 1992 . 10.1016/S0021-9258(18)48432-3 . 1370465 . free .
• Pandey A, Shao H, Marks RM, etal . Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. . Science . 268 . 5210 . 567–9 . 1995 . 7536959 . 10.1126/science.7536959 . 1995Sci...268..567P .
• Suzuki H, Fukunishi Y, Kagawa I, etal . Protein-protein interaction panel using mouse full-length cDNAs. . Genome Res. . 11 . 10 . 1758–65 . 2001 . 11591653 . 10.1101/gr.180101 . 311163 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Link CD, Taft A, Kapulkin V, etal . Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. . Neurobiol. Aging . 24 . 3 . 397–413 . 2003 . 12600716 . 10.1016/S0197-4580(02)00224-5 . 22679483 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Nousiainen M, Silljé HH, Sauer G, etal . Phosphoproteome analysis of the human mitotic spindle. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 10.1073/pnas.0507066103 . 1459365 . 2006PNAS..103.5391N . free .

Notes and References

1. Dixit VM, Green S, Sarma V, Holzman LB, Wolf FW, O'Rourke K, Ward PA, Prochownik EV, Marks RM . Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin . J Biol Chem . 265 . 5 . 2973–8 . Mar 1990 . 10.1016/S0021-9258(19)39896-5 . 2406243 . free .
2. Holzman LB, Marks RM, Dixit VM . A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein . Mol Cell Biol . 10 . 11 . 5830–8 . Dec 1990 . 2233719 . 361366 . 10.1128/MCB.10.11.5830.
3. Web site: Entrez Gene: TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial).
4. Web site: Entrez Gene: TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial).