TNB-486 explained

Type:mab
Target:CD19, CD3
Synonyms:AZD0486
Unii:3QW12I37H1

TNB-486 (also known as AZD0486)[1] "is a novel CD19xCD3 bispecific T-cell engager (TCE) that incorporates a unique anti-CD3 moiety designed to reduce cytokine release syndrome by binding to T-cells with low affinity".[2] The drug is developed for cancer by AstraZeneca since its acquisition of TeneoTwo in 2022.[3] [4] [5]

Notes and References

  1. Web site: AZD 0486 - AdisInsight . adisinsight.springer.com . 19 November 2023.
  2. Hou . Jing-Zhou . Jacobs . Ryan . Cho . Seok-Goo . Devata . Sumana . Gaballa . Sameh . Yoon . Dok Hyun . Stevens . Don A. . Kim . Jin Seok . Buelow . Ben . Nair . Ranjit . Interim Results of the Phase 1 Study of Tnb-486, a Novel CD19xCD3 T-Cell Engager, in Patients with Relapsed/Refractory (R/R) B-NHL . Blood . 15 November 2022 . 140 . Supplement 1 . 1474–1475 . 10.1182/blood-2022-166385. free .
  3. Web site: AstraZeneca to acquire TeneoTwo and its clinical-stage T-cell engager, strengthening haematological cancer pipeline . 19 November 2023.
  4. Nair . Ranjit . Jacobs . Ryan . Cho . Seok-Goo . Devata . Sumana . Gaballa . Sameh . Yoon . Dok Hyun . Stevens . Don A. . Kim . Jin Seok . Shah . Nirav Niranjan . Brennan . Denise Marie . Law . Jason . Chen . Rob . Forcina . Alessandra . Buelow . Ben . Hou . Jing-Zhou . High complete response rate with TNB-486 in relapsed/refractory follicular lymphoma: Interim results from an ongoing phase 1 study. . Journal of Clinical Oncology . 1 June 2023 . 41 . 16_suppl . 7524 . 10.1200/JCO.2023.41.16_suppl.7524. 259079121 .
  5. Malik-Chaudhry . Harbani K. . Prabhakar . Kirthana . Ugamraj . Harshad S. . Boudreau . Andrew A. . Buelow . Benjamin . Dang . Kevin . Davison . Laura M. . Harris . Katherine E. . Jorgensen . Brett . Ogana . Heather . Pham . Duy . Schellenberger . Ute . Van Schooten . Wim . Buelow . Roland . Iyer . Suhasini . Trinklein . Nathan D. . Rangaswamy . Udaya S. . TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL . mAbs . 2021 . 13 . 1 . 1890411 . 10.1080/19420862.2021.1890411 . 1942-0862. free . 33818299 . 8023237 .

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