TMPRSS11D explained

Transmembrane protease, serine 11D is an enzyme that in humans is encoded by the TMPRSS11D gene.^{[1] [2] [3]}

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.

Further reading

• Takahashi M . Localization of human airway trypsin-like protease in the airway: an immunohistochemical study . Histochem. Cell Biol. . 115 . 3 . 181–7 . 2001 . 11326745 . 10.1007/s004180000243 . vanc. Sano T . Yamaoka K . 3 . Kamimura . T . Umemoto . N . Nishitani . H . Yasuoka . S . 25025224 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Miki M . Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells . J. Med. Invest. . 50 . 1–2 . 95–107 . 2003 . 12630574 . vanc. Nakamura Y . Takahashi A . 3 . Nakaya . Y . Eguchi . H . Masegi . T . Yoneda . K . Yasuoka . S . Sone . S .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Iwakiri K . Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris . J. Invest. Dermatol. . 122 . 4 . 937–44 . 2004 . 15102084 . 10.1111/j.0022-202X.2004.22415.x . vanc. Ghazizadeh M . Jin E . 3 . Fujiwara . Masakazu . Takemura . Tamiko . Takezaki . Shin-Ichiro . Kawana . Seiji . Yasuoka . Susumu . Kawanami . Oichi . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Matsushima R . Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway . Am. J. Physiol. Lung Cell Mol. Physiol. . 290 . 2 . L385–95 . 2006 . 16199437 . 10.1152/ajplung.00098.2005 . vanc. Takahashi A . Nakaya Y . 3 . Maezawa . H . Miki . M . Nakamura . Y . Ohgushi . F . Yasuoka . S .
• Chokki M . Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells . FEBS J. . 272 . 24 . 6387–99 . 2006 . 16336275 . 10.1111/j.1742-4658.2005.05035.x . vanc. Eguchi H . Hamamura I . 3 . Mitsuhashi . Hiroaki . Kamimura . Takashi . 34294232 . free .
• Böttcher E . Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium . J. Virol. . 80 . 19 . 9896–8 . 2006 . 16973594 . 10.1128/JVI.01118-06 . 1617224 . vanc. Matrosovich T . Beyerle M . 3 . Klenk . H.-D. . Garten . W. . Matrosovich . M. .

Notes and References

1. Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, Yasuoka S . Cloning and characterization of the cDNA for human airway trypsin-like protease . J Biol Chem . 273 . 19 . 11895–901 . Jun 1998 . 9565616 . 10.1074/jbc.273.19.11895 . free .
2. Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, Sano T . Purification, characterization, and localization of a novel trypsin-like protease found in the human airway . Am J Respir Cell Mol Biol . 16 . 3 . 300–8 . Apr 1997 . 9070615 . 10.1165/ajrcmb.16.3.9070615.
3. Web site: Entrez Gene: TMPRSS11D transmembrane protease, serine 11D. 2017-09-15. 2024-04-30. https://web.archive.org/web/20240430165342/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9407. live.