TMEPAI explained
Transmembrane prostate androgen-induced protein is a protein that in humans is encoded by the PMEPA1 gene.[1] [2]
Interactions
TMEPAI has been shown to interact with NEDD4.[3]
Further reading
- Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S . Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4 . The Biochemical Journal . 351 Pt 3 . 3. 557–65 . Nov 2000 . 11042109 . 1221394 . 10.1042/0264-6021:3510557 .
- Rae FK, Hooper JD, Nicol DL, Clements JA . Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors . Molecular Carcinogenesis . 32 . 1 . 44–53 . Sep 2001 . 11568975 . 10.1002/mc.1063 . 46602128 . free .
- Brunschwig EB, Wilson K, Mack D, Dawson D, Lawrence E, Willson JK, Lu S, Nosrati A, Rerko RM, Swinler S, Beard L, Lutterbaugh JD, Willis J, Platzer P, Markowitz S . PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer . Cancer Research . 63 . 7 . 1568–75 . Apr 2003 . 12670906 .
- Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S . PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression . Cancer Research . 63 . 15 . 4299–304 . Aug 2003 . 12907594 .
- Giannini G, Ambrosini MI, Di Marcotullio L, Cerignoli F, Zani M, MacKay AR, Screpanti I, Frati L, Gulino A . EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer . Molecular Carcinogenesis . 38 . 4 . 188–200 . Dec 2003 . 14639658 . 10.1002/mc.10162 . 22894125 .
- Huda Zoghbi . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
Notes and References
- Xu LL, Shanmugam N, Segawa T, Sesterhenn IA, McLeod DG, Moul JW, Srivastava S . A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate . Genomics . 66 . 3 . 257–63 . Jun 2000 . 10873380 . 10.1006/geno.2000.6214 .
- Web site: Entrez Gene: TMEPAI transmembrane, prostate androgen induced RNA.
- Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S . PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression . Cancer Research . 63 . 15 . 4299–304 . Aug 2003 . 12907594 .
