NDC1 explained

Nucleoporin NDC1 is a protein that in humans is encoded by the TMEM48 gene.^{[1] [2] [3]} It anchors aladin to the nuclear pore complex.^[4]

Further reading

• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Nousiainen M, Silljé HH, Sauer G, etal . Phosphoproteome analysis of the human mitotic spindle. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 10.1073/pnas.0507066103 . 1459365 . 2006PNAS..103.5391N . free .
• Mansfeld J, Güttinger S, Hawryluk-Gara LA, etal . The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. . Mol. Cell . 22 . 1 . 93–103 . 2006 . 16600873 . 10.1016/j.molcel.2006.02.015 . free .
• Stavru F, Hülsmann BB, Spang A, etal . NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes. . J. Cell Biol. . 173 . 4 . 509–19 . 2006 . 16702233 . 10.1083/jcb.200601001 . 2063861 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Lau CK, Delmar VA, Forbes DJ . Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue . Anat Rec A . 288 . 7 . 681–94 . Aug 2006 . 16779818 . 3049984. 10.1002/ar.a.20335 .
2. Schirmer EC, Florens L, Guan T, Yates JR 3rd, Gerace L . Nuclear membrane proteins with potential disease links found by subtractive proteomics . Science . 301 . 5638 . 1380–2 . Sep 2003 . 12958361 . 10.1126/science.1088176 . 2003Sci...301.1380S . 23832536 .
3. Web site: Entrez Gene: TMEM48 transmembrane protein 48.
4. Kind. Barbara. Koehler. Katrin. Lorenz. Mike. Huebner. Angela. The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope. Biochemical and Biophysical Research Communications. December 2009. 390. 2. 205–210. 10.1016/j.bbrc.2009.09.080. 19782045.