Transmembrane protein 151b explained

Transmembrane protein 151B is a protein that in humans is encoded by the TMEM151B gene.[1]

Nomenclature

The Transmembrane protein 151B gene is also known as TMEM151B, C6orf137, and bA444E17.5.[2]

Gene

The gene is located on the positive strand of chromosome 6 at the location 6p21.1 from the chromosome position 44270450 to 44279444, for a total length of 8,995 base pairs.[3] It is a complex locus that contains both TMEM151B and SPATS1.[4] TMEM151B has one paralog: TMEM151A.[5]

Transcript

The mRNA contains 3 exons, with a transcribed mRNA length of 4911bp, and the coding region containing 1701bp.

Protein

The protein has a length of 566 amino acids and contains two transmembrane domains. According to Compute pI/Mw,  molecular weight of approximately 61 kDa, which matches the weight listed on NCBI, and a theoretical isoelectric point of 6.72.[6] The human TMEM151B protein composition is poor in lysine and arginine, lysine comprising 1.4% of the amino acids and arginine making up 0.8% of the total protein. The mouse ortholog is also arginine poor.[7]

Expression

RNA-seq gene expression profiling shows high expression in the brain, and notable expression in the testes.[8] NCBI geo profiles similarly show localization to the brain tissues.[9] Within the mouse brain, TMEM151B has high expression particularly within the cerebellum, medulla, and olfactory bulb according to the Allen Brain Atlas.

Protein interactions

The TMEM151B protein interacts with one other protein according to BioGRID.[10]

Homology and evolution

The TMEM151B gene is conserved within most vertebrates, and appears to be conserved within some invertebrates. Its paralog, TMEM151A, has a 47.7% sequence identity with TMEM151B.[12] The evolution rate is relatively slow: between the rate of change in fibrinogen alpha and cytochrome c.[5] [13]

Research

Alternative splicing of TMEM151B along with 4 other genes were linked to colorectal cancer.[14] It was also found to be up-regulated in post-menopausal breast cancer.[15] [16] A SNP found within TMEM151B is associated with the development of lean muscle.[17]

Further reading

Notes and References

  1. Web site: Entrez Gene: Transmembrane protein 151B .
  2. Web site: transmembrane protein 151B [Homo sapiens] - Protein - NCBI]. 2021-09-29. www.ncbi.nlm.nih.gov.
  3. Web site: Homo sapiens transmembrane protein 151B (TMEM151B), mRNA - NCBI. 2021-09-29. www.ncbi.nlm.nih.gov.
  4. Web site: AceView: Gene:TMEM151BandSPATS1, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView.. 2021-10-04. www.ncbi.nlm.nih.gov.
  5. Web site: BLAST: Basic Local Alignment Search Tool. 2022-01-13. blast.ncbi.nlm.nih.gov.
  6. Web site: ExPASy - Compute pI/Mw tool. 2022-01-13. web.expasy.org.
  7. Web site: SAPS < Sequence Statistics < EMBL-EBI. 2022-01-13. www.ebi.ac.uk.
  8. Web site: TMEM151B transmembrane protein 151B [Homo sapiens (human)] - Gene - NCBI]. 2022-01-13. www.ncbi.nlm.nih.gov.
  9. Web site: GDS596 / 213678_at. 2022-01-13. www.ncbi.nlm.nih.gov.
  10. Web site: TMEM151B (RP11-444E17.5) Result Summary BioGRID. 2022-01-13. thebiogrid.org.
  11. Web site: SREBF2 Gene - GeneCards SRBP2 Protein SRBP2 Antibody. 2022-01-13. www.genecards.org.
  12. Web site: Clustal Omega < Multiple Sequence Alignment < EMBL-EBI. 2022-01-13. www.ebi.ac.uk.
  13. Web site: TimeTree :: The Timescale of Life. 2022-01-13. www.timetree.org.
  14. Liu J, Li H, Shen S, Sun L, Yuan Y, Xing C . Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer . Journal of Cancer . 9 . 10 . 1754–1764 . 2018 . 29805701 . 10.7150/jca.24569 . 5968763 .
  15. Carter JM, Nair AA, Davila JI, Heinzen EP, Hoskin TL, Winham SJ, Radisky DC, Visscher DW, Degnim AC . 6 . 2019-02-15. Abstract P3-08-10: A unique coding and non-coding benign breast transcriptome in post-menopausal ER+ breast cancer. Poster Session Abstracts. 79 . 4_Supplement . American Association for Cancer Research. 10.1158/1538-7445.sabcs18-p3-08-10. 164377723 .
  16. Qian D, Zheng Q, Wu D, Ye B, Qian Y, Zhou T, Qiu J, Meng X . 6 . Integrated Analysis of ceRNA Network Reveals Prognostic and Metastasis Associated Biomarkers in Breast Cancer . Frontiers in Oncology . 11 . 670138 . 2021-05-13 . 34055638 . 10.3389/fonc.2021.670138 . 8158160 . free .
  17. Pei YF, Hu WZ, Yang XL, Wei XT, Feng GJ, Zhang H, Shen H, Tian Q, Deng HW, Zhang L . 6 . Two functional variants at 6p21.1 were associated with lean mass . Skeletal Muscle . 9 . 1 . 28 . November 2019 . 31757224 . 10.1186/s13395-019-0212-3 . 6874818 . free .

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