TMEM123 explained

Porimin is a protein that in humans is encoded by the TMEM123 gene.^{[1] [2]}

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins.

Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis.

Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.^[3]

Further reading

• Dekker J, Rossen JW, Büller HA, Einerhand AW . The MUC family: an obituary. . Trends Biochem. Sci. . 27 . 3 . 126–31 . 2002 . 11893509 . 10.1016/S0968-0004(01)02052-7 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Zhang C, Xu Y, Gu J, Schlossman SF . A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 11 . 6290–5 . 1998 . 9600958 . 10.1073/pnas.95.11.6290 . 27661 . 1998PNAS...95.6290Z . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bonkobara M, Das A, Takao J, etal . Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. . Br. J. Dermatol. . 148 . 4 . 654–64 . 2003 . 12752121 . 10.1046/j.1365-2133.2003.05244.x . 21635573 .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .

Notes and References

1. Ma F, Zhang C, Prasad KV, Freeman GJ, Schlossman SF . Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death . Proc Natl Acad Sci U S A . 98 . 17 . 9778–83 . Aug 2001 . 11481458 . 55529 . 10.1073/pnas.171322898 . 2001PNAS...98.9778M . free .
2. Web site: Entrez Gene: TMEM123 transmembrane protein 123.
3. Web site: Entrez Gene: TMEM123 transmembrane protein 123.