TMED2 explained

Transmembrane emp24 domain-containing protein 2 is a protein that in humans is encoded by the TMED2 gene.^{[1] [2]}

Interactions

TMED2 has been shown to interact with GORASP1^[3] and GORASP2.^[3]

Further reading

• Fiedler K, Veit M, Stamnes MA, Rothman JE . Bimodal interaction of coatomer with the p24 family of putative cargo receptors . Science . 273 . 5280 . 1396–9 . September 1996 . 8703076 . 10.1126/science.273.5280.1396 . 1996Sci...273.1396F . 13159384 .
• Gommel D, Orci L, Emig EM, Hannah MJ, Ravazzola M, Nickel W, Helms JB, Wieland FT, Sohn K . p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway . FEBS Letters . 447 . 2–3 . 179–85 . March 1999 . 10214941 . 10.1016/S0014-5793(99)00246-X . 41832392 . free .
• Majoul I, Straub M, Hell SW, Duden R, Söling HD . KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET . Developmental Cell . 1 . 1 . 139–53 . July 2001 . 11703931 . 10.1016/S1534-5807(01)00004-1 . free .
• Barr FA, Preisinger C, Kopajtich R, Körner R . Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus . The Journal of Cell Biology . 155 . 6 . 885–91 . December 2001 . 11739402 . 2150891 . 10.1083/jcb.200108102 .
• Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, Hauri HP . Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46 . The Journal of Biological Chemistry . 279 . 45 . 47242–53 . November 2004 . 15308636 . 10.1074/jbc.M406644200 . free .
• Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P . TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity . Nature . 440 . 7088 . 1208–12 . April 2006 . 16641999 . 10.1038/nature04667 . 2006Natur.440.1208C . 4349251 .
• Luo W, Wang Y, Reiser G . p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking . The Journal of Biological Chemistry . 282 . 41 . 30246–55 . October 2007 . 17693410 . 10.1074/jbc.M703205200 . free .

Notes and References

1. Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I . Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking . The Journal of Biological Chemistry . 271 . 29 . 17183–9 . July 1996 . 8663407 . 10.1074/jbc.271.29.17183 . free .
2. Web site: Entrez Gene: TMED2 transmembrane emp24 domain trafficking protein 2.
3. Barr FA, Preisinger C, Kopajtich R, Körner R . Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus . The Journal of Cell Biology . 155 . 6 . 885–91 . December 2001 . 11739402 . 2150891 . 10.1083/jcb.200108102 .