TMED10 explained
Transmembrane emp24 domain-containing protein 10 is a protein that in humans is encoded by the TMED10 gene.[1] [2] [3]
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.
Further reading
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Gommel D, Orci L, Emig EM, etal . p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway . FEBS Lett. . 447 . 2–3 . 179–85 . 1999 . 10214941 . 10.1016/S0014-5793(99)00246-X . free .
- Hörer J, Blum R, Feick P, etal . A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II . DNA Seq. . 10 . 2 . 121–6 . 1999 . 10376215 . 10.3109/10425179909008429 .
- Wang H, Kazanietz MG . Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain . J. Biol. Chem. . 277 . 6 . 4541–50 . 2002 . 11689559 . 10.1074/jbc.M107150200 . free .
- Majoul I, Straub M, Hell SW, etal . KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET . Dev. Cell . 1 . 1 . 139–53 . 2001 . 11703931 . 10.1016/S1534-5807(01)00004-1 . free .
- Gommel DU, Memon AR, Heiss A, etal . Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23 . EMBO J. . 20 . 23 . 6751–60 . 2002 . 11726511 . 10.1093/emboj/20.23.6751 . 125325 .
- Barr FA, Preisinger C, Kopajtich R, Körner R . Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus . J. Cell Biol. . 155 . 6 . 885–91 . 2002 . 11739402 . 10.1083/jcb.200108102 . 2150891 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Heilig R, Eckenberg R, Petit JL, etal . The DNA sequence and analysis of human chromosome 14 . Nature . 421 . 6923 . 601–7 . 2003 . 12508121 . 10.1038/nature01348 . free .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Brandenberger R, Wei H, Zhang S, etal . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
- Breuza L, Halbeisen R, Jenö P, etal . Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46 . J. Biol. Chem. . 279 . 45 . 47242–53 . 2004 . 15308636 . 10.1074/jbc.M406644200 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Chen F, Hasegawa H, Schmitt-Ulms G, etal . TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity . Nature . 440 . 7088 . 1208–12 . 2006 . 16641999 . 10.1038/nature04667 . 4349251 .
- Chi A, Valencia JC, Hu ZZ, etal . Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes . J. Proteome Res. . 5 . 11 . 3135–44 . 2007 . 17081065 . 10.1021/pr060363j .
Notes and References
- Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, etal . Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease . Nature . 375 . 6534 . 754–60 . Aug 1995 . 7596406 . 10.1038/375754a0 . 4308372 .
- Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I . Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking . J Biol Chem . 271 . 29 . 17183–9 . Sep 1996 . 8663407 . 10.1074/jbc.271.29.17183 . free .
- Web site: Entrez Gene: TMED10 transmembrane emp24-like trafficking protein 10 (yeast).