TLX1 explained

T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11.^{[1] [2] [3] [4] [5]}

Interactions

TLX1 has been shown to interact with PPP1CC,^[6] PPP2CB^[6] and PPP2CA.^[6]

References

Further reading

• Allen TD, Zhu YX, Hawley TS, Hawley RG . TALE homeoproteins as HOX11-interacting partners in T-cell leukemia . Leukemia & Lymphoma . 39 . 3–4 . 241–56 . Oct 2000 . 11342305 . 10.3109/10428190009065824 . 27407074 .
• Lu M, Zhang N, Ho AD . Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells . Oncogene . 7 . 7 . 1325–30 . Jul 1992 . 1352396 .
• Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH . HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24 . Proceedings of the National Academy of Sciences of the United States of America . 88 . 20 . 8900–4 . Oct 1991 . 1681546 . 52618 . 10.1073/pnas.88.20.8900 . free . 1991PNAS...88.8900K .
• Lu M, Gong ZY, Shen WF, Ho AD . The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein . The EMBO Journal . 10 . 10 . 2905–10 . Oct 1991 . 1717256 . 453003 . 10.1002/j.1460-2075.1991.tb07840.x.
• Dear TN, Colledge WH, Carlton MB, Lavenir I, Larson T, Smith AJ, Warren AJ, Evans MJ, Sofroniew MV, Rabbitts TH . The Hox11 gene is essential for cell survival during spleen development . Development . 121 . 9 . 2909–15 . Sep 1995 . 10.1242/dev.121.9.2909 . 7555717 .
• Dear TN, Sanchez-Garcia I, Rabbitts TH . The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes . Proceedings of the National Academy of Sciences of the United States of America . 90 . 10 . 4431–5 . May 1993 . 8099440 . 46525 . 10.1073/pnas.90.10.4431 . free . 1993PNAS...90.4431D .
• Kawabe T, Muslin AJ, Korsmeyer SJ . HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint . Nature . 385 . 6615 . 454–8 . Jan 1997 . 9009195 . 10.1038/385454a0 . 1997Natur.385..454K . 608633 .
• Brake RL, Kees UR, Watt PM . Multiple negative elements contribute to repression of the HOX11 proto-oncogene . Oncogene . 17 . 14 . 1787–95 . Oct 1998 . 9778044 . 10.1038/sj.onc.1202078 . free .
• Zhang N, Shen W, Hawley RG, Lu M . HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization . Oncogene . 18 . 13 . 2273–9 . Apr 1999 . 10327073 . 10.1038/sj.onc.1202545 . free .
• Watt PM, Ranford PR, Kees UR . Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line . Gene . 234 . 1 . 169–76 . Jun 1999 . 10393251 . 10.1016/S0378-1119(99)00157-2 .
• Brake RL, Kees UR, Watt PM . A complex containing PBX2 contributes to activation of the proto-oncogene HOX11 . Biochemical and Biophysical Research Communications . 294 . 1 . 23–34 . May 2002 . 12054735 . 10.1016/S0006-291X(02)00426-6 .
• Bodenmiller DM, Baxter CS, Hansen DV, Potter SS . Phylogenetic analysis of Hoxa 11 sequences reveals absence of transposable elements, conservation of transcription factor binding sites, and suggests antisense coding function . DNA Sequence . 13 . 2 . 77–83 . Apr 2002 . 12180349 . 10.1080/10425170290029981 . 38713800 .
• Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Méchinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N . Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951 . Blood . 103 . 2 . 442–50 . Jan 2004 . 14504110 . 10.1182/blood-2003-05-1495 . free .
• Hoffmann K, Dixon DN, Greene WK, Ford J, Taplin R, Kees UR . A microarray model system identifies potential new target genes of the proto-oncogene HOX11 . Genes, Chromosomes & Cancer . 41 . 4 . 309–20 . Dec 2004 . 15384172 . 10.1002/gcc.20104 . 19475690 .
• Riz I, Hawley RG . G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia . Oncogene . 24 . 36 . 5561–75 . Aug 2005 . 15897879 . 2408753 . 10.1038/sj.onc.1208727 .
• Heidari M, Rice KL, Phillips JK, Kees UR, Greene WK . The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells . Leukemia . 20 . 2 . 304–12 . Feb 2006 . 16357834 . 10.1038/sj.leu.2404071 . free .
• Chen E, Lim MS, Rosic-Kablar S, Liu J, Jolicoeur P, Dubé ID, Hough MR . Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice . Oncogene . 25 . 18 . 2575–87 . Apr 2006 . 16407851 . 10.1038/sj.onc.1209285 . free .

Notes and References

1. Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ . Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia . Science . 253 . 5015 . 79–82 . Jul 1991 . 1676542 . 10.1126/science.1676542 . 1991Sci...253...79H .
2. McAlpine PJ, Shows TB . Nomenclature for human homeobox genes . Genomics . 7 . 3 . 460 . Jul 1990 . 1973146 . 10.1016/0888-7543(90)90186-X .
3. Web site: Entrez Gene: TLX1 T-cell leukemia homeobox 1.
4. Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH . HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24 . Proceedings of the National Academy of Sciences of the United States of America . 88 . 20 . 8900–4 . Oct 1991 . 52618 . 1681546 . 10.1073/pnas.88.20.8900. free . 1991PNAS...88.8900K .
5. Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J . A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14) . Blood . 78 . 11 . 2996–3003 . Dec 1991 . 10.1182/blood.V78.11.2996.2996 . 1683261. free .
6. Kawabe T, Muslin AJ, Korsmeyer SJ . HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint . Nature . 385 . 6615 . 454–8 . Jan 1997 . 9009195 . 10.1038/385454a0 . 1997Natur.385..454K . 608633 .