SEC62 explained

Translocation protein SEC62 is a protein that in humans is encoded by the SEC62 gene.^{[1] [2] [3]}

Function

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

Further reading

• Daimon M, Susa S, Kato T . Fine structure of the human translocation protein 1 (HTP1/TLOC1) gene . IUBMB Life . 48 . 6 . 619–24 . 2000 . 10683767 . 10.1080/713803565 . 10297001 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Jung V, Kindich R, Kamradt J, etal . Genomic and expression analysis of the 3q25-q26 amplification unit reveals TLOC1/SEC62 as a probable target gene in prostate cancer . Mol. Cancer Res. . 4 . 3 . 169–76 . 2006 . 16547154 . 10.1158/1541-7786.MCR-05-0165 . free .
• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Daimon M, Susa S, Suzuki K, Kato T, Yamatani K, Sasaki H . Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp1) . Biochem Biophys Res Commun . 230 . 1 . 100–4 . Feb 1997 . 9020021 . 10.1006/bbrc.1996.5892 .
2. Meyer HA, Grau H, Kraft R, Kostka S, Prehn S, Kalies KU, Hartmann E . Mammalian Sec61 is associated with Sec62 and Sec63 . J Biol Chem . 275 . 19 . 14550–7 . Jun 2000 . 10799540 . 10.1074/jbc.275.19.14550 . free .
3. Web site: Entrez Gene: TLOC1 translocation protein 1.