TLL1 explained

Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.^{[1] [2]}

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites.^[2]

Further reading

• Takahara K, Brevard R, Hoffman GG, etal . Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1. . Genomics . 34 . 2 . 157–165 . 1997 . 8661043 . 10.1006/geno.1996.0260 .
• Scott IC, Blitz IL, Pappano WN, etal . Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. . Dev. Biol. . 213 . 2 . 283–300 . 1999 . 10479448 . 10.1006/dbio.1999.9383 . free .
• Scott IC, Imamura Y, Pappano WN, etal . Bone morphogenetic protein-1 processes probiglycan. . J. Biol. Chem. . 275 . 39 . 30504–30511 . 2000 . 10896944 . 10.1074/jbc.M004846200 . free .
• Uzel MI, Scott IC, Babakhanlou-Chase H, etal . Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures. . J. Biol. Chem. . 276 . 25 . 22537–22543 . 2001 . 11313359 . 10.1074/jbc.M102352200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ge G, Zhang Y, Steiglitz BM, Greenspan DS . Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains. . J. Biol. Chem. . 281 . 16 . 10786–10798 . 2006 . 16507574 . 10.1074/jbc.M511111200 . free .

Notes and References

1. Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS . Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19 . Cytogenet Cell Genet . 86 . 1 . 64–65 . Oct 1999 . 10516436 . 10.1159/000015412 . 42081614 .
2. Web site: Entrez Gene: TLL1 tolloid-like 1.