TLE4 explained
Transducin-like enhancer protein 4 is a protein that in humans is encoded by the TLE4 gene.[1] [2]
Interactions
TLE4 has been shown to interact with PAX5.[3] [4]
Further reading
- Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S . Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins . Nature Genetics . 2 . 2 . 119–27 . October 1992 . 1303260 . 10.1038/ng1092-119 . 32142845 .
- Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 6 . 5 . 337–45 . October 1999 . 10574462 . 10.1093/dnares/6.5.337 . free .
- Eberhard D, Jiménez G, Heavey B, Busslinger M . Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family . The EMBO Journal . 19 . 10 . 2292–303 . May 2000 . 10811620 . 384353 . 10.1093/emboj/19.10.2292 .
- Milili M, Gauthier L, Veran J, Mattei MG, Schiff C . A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes . Immunology . 106 . 4 . 447–55 . August 2002 . 12153506 . 1782747 . 10.1046/j.1365-2567.2002.01456.x .
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
- Heimbucher T, Murko C, Bajoghli B, Aghaallaei N, Huber A, Stebegg R, Eberhard D, Fink M, Simeone A, Czerny T . Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors . Molecular and Cellular Biology . 27 . 1 . 340–51 . January 2007 . 17060451 . 1800652 . 10.1128/MCB.00811-06 .
Notes and References
- Miyasaka H, Choudhury BK, Hou EW, Li SS . Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein . European Journal of Biochemistry . 216 . 1 . 343–52 . August 1993 . 8365415 . 10.1111/j.1432-1033.1993.tb18151.x . free .
- Web site: Entrez Gene: TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila).
- Eberhard D, Jiménez G, Heavey B, Busslinger M . Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family . The EMBO Journal . 19 . 10 . 2292–303 . May 2000 . 10811620 . 384353 . 10.1093/emboj/19.10.2292 .
- Milili M, Gauthier L, Veran J, Mattei MG, Schiff C . A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes . Immunology . 106 . 4 . 447–55 . August 2002 . 12153506 . 1782747 . 10.1046/j.1365-2567.2002.01456.x .
