TLE3 explained
Transducin-like enhancer protein 3 is a protein that in humans is encoded by the TLE3 gene.[1] [2]
TLE3 expression has been linked to higher survival rates for lung cancer patients.[3]
Further reading
- Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S . Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins . Nature Genetics . 2 . 2 . 119–27 . Oct 1992 . 1303260 . 10.1038/ng1092-119 . 32142845 .
- Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S . Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia . Genomics . 31 . 1 . 58–64 . Jan 1996 . 8808280 . 10.1006/geno.1996.0009 . free .
- Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK . Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta . The Journal of Biological Chemistry . 275 . 24 . 18418–23 . Jun 2000 . 10748198 . 10.1074/jbc.M910211199 . free .
- Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 7 . 4 . 273–81 . Aug 2000 . 10997877 . 10.1093/dnares/7.4.271 . free .
- Yao J, Lai E, Stifani S . The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription . Molecular and Cellular Biology . 21 . 6 . 1962–72 . Mar 2001 . 11238932 . 86788 . 10.1128/MCB.21.6.1962-1972.2001 .
- Nuthall HN, Joachim K, Palaparti A, Stifani S . A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression . The Journal of Biological Chemistry . 277 . 52 . 51049–57 . Dec 2002 . 12397081 . 10.1074/jbc.M111660200 . free .
- López-Ríos J, Tessmar K, Loosli F, Wittbrodt J, Bovolenta P . Six3 and Six6 activity is modulated by members of the groucho family . Development . 130 . 1 . 185–95 . Jan 2003 . 12441302 . 10.1242/dev.00185 . free .
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . Oct 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .
- Tu LC, Yan X, Hood L, Lin B . Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells . Molecular & Cellular Proteomics . 6 . 4 . 575–88 . Apr 2007 . 17220478 . 10.1074/mcp.M600249-MCP200 . free .
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
Notes and References
- Miyasaka H, Choudhury BK, Hou EW, Li SS . Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein . European Journal of Biochemistry . 216 . 1 . 343–52 . Aug 1993 . 8365415 . 10.1111/j.1432-1033.1993.tb18151.x . free .
- Web site: Entrez Gene: TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila).
- Web site: Research update from the MCM team (February 2024). World Community Grid. 16 February 2024. 21 May 2024.