TIMM9 explained

Mitochondrial import inner membrane translocase subunit Tim9 is an enzyme that in humans is encoded by the TIMM9 gene.^{[1] [2] [3]}

TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space.

These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM]

Further reading

• Webb CT, Gorman MA, Lazarou M, etal . Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller . Mol. Cell . 21 . 1 . 123–33 . 2006 . 16387659 . 10.1016/j.molcel.2005.11.010 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Vial S, Lu H, Allen S, etal . Assembly of Tim9 and Tim10 into a functional chaperone . J. Biol. Chem. . 277 . 39 . 36100–8 . 2002 . 12138093 . 10.1074/jbc.M202310200 . free .
• Rothbauer U, Hofmann S, Mühlenbein N, etal . Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria . J. Biol. Chem. . 276 . 40 . 37327–34 . 2001 . 11489896 . 10.1074/jbc.M105313200 . free .
• Bauer MF, Rothbauer U, Mühlenbein N, etal . The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom . FEBS Lett. . 464 . 1–2 . 41–7 . 2000 . 10611480 . 10.1016/S0014-5793(99)01665-8 . free .

Notes and References

1. Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL . The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins . Genomics . 61 . 3 . 259–67 . Feb 2000 . 10552927 . 10.1006/geno.1999.5966 .
2. Muhlenbein N, Hofmann S, Rothbauer U, Bauer MF . Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria . J Biol Chem . 279 . 14 . 13540–6 . Mar 2004 . 14726512 . 10.1074/jbc.M312485200 . free .
3. Web site: Entrez Gene: TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast).