TIMM10B explained

Mitochondrial import inner membrane translocase subunit Tim9 B is an enzyme that in humans is encoded by the FXC1 gene.^{[1] [2]}

FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM]

Further reading

• Hadjiargyrou M . Cloning of a novel cDNA expressed during the early stages of fracture healing . Biochem. Biophys. Res. Commun. . 249 . 3 . 879–84 . 1998 . 9731230 . 10.1006/bbrc.1998.9167 . vanc. Halsey MF . Ahrens W . 3 . Rightmire . Eric P. . McLeod . Kenneth J. . Rubin . Clinton T. .
• Bauer MF . The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom . FEBS Lett. . 464 . 1–2 . 41–7 . 2000 . 10611480 . 10.1016/S0014-5793(99)01665-8 . vanc. Rothbauer U . Mühlenbein N . 3 . Smith . Richard J.H. . Gerbitz . Klaus-Dieter . Neupert . Walter . Brunner . Michael . Hofmann . Sabine . 27484018 . free .
• Rothbauer U . Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria . J. Biol. Chem. . 276 . 40 . 37327–34 . 2001 . 11489896 . 10.1074/jbc.M105313200 . vanc. Hofmann S . Mühlenbein N . 3 . Paschen . SA . Gerbitz . KD . Neupert . W . Brunner . M . Bauer . MF . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF . Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria . J. Biol. Chem. . 279 . 14 . 13540–6 . 2004 . 14726512 . 10.1074/jbc.M312485200 . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Kimura K . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .

Notes and References

1. Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL . The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins . Genomics . 61 . 3 . 259–67 . Feb 2000 . 10552927 . 10.1006/geno.1999.5966 .
2. Web site: Entrez Gene: FXC1 fracture callus 1 homolog (rat).