TIE1 explained
| tyrosine kinase with immunoglobulin-like and EGF-like domains 1 |
| Hgncid: | 11809 |
| Symbol: | TIE1 |
| Altsymbols: | TIE, JTK14 |
| Entrezgene: | 7075 |
| Omim: | 600222 |
| Refseq: | NM_005424 |
| Uniprot: | P35590 |
| Ecnumber: | 2.7.1.112 |
| Chromosome: | 1 |
| Arm: | p |
| Band: | 34 |
| Locussupplementarydata: | -p33 |
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.[1]
Function
TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells[2] and platelets.[3] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.[4]
Notes and References
- Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K . A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains . Molecular and Cellular Biology . 12 . 4 . 1698–707 . April 1992 . 1312667 . 369613 . 10.1128/mcb.12.4.1698.
- Rodewald HR, Sato TN . Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells . Oncogene . 12 . 2 . 397–404 . January 1996 . 8570217 .
- Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP . Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets . Journal of Vascular Research . 37 . 6 . 437–42 . 2000 . 11146396 . 10.1159/000054075 . 43509019 .
- Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP . Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules . Biochemical and Biophysical Research Communications . 371 . 3 . 475–9 . July 2008 . 18448073 . 10.1016/j.bbrc.2008.04.091 .
