TICAM2 explained

TIR domain-containing adapter molecule 2 is a protein that in humans is encoded by the TICAM2 gene.^[1]

TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM]^[2]

Further reading

• Sullivan C, Postlethwait JH, Lage CR, etal . Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates . J. Immunol. . 178 . 7 . 4517–27 . 2007 . 17372010 . 10.4049/jimmunol.178.7.4517. free .
• Rowe DC, McGettrick AF, Latz E, etal . The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction . Proc. Natl. Acad. Sci. U.S.A. . 103 . 16 . 6299–304 . 2006 . 16603631 . 10.1073/pnas.0510041103 . 1458872 . free . 2006PNAS..103.6299R .
• Yamamoto M, Sato S, Hemmi H, etal . TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway . Nat. Immunol. . 4 . 11 . 1144–50 . 2003 . 14556004 . 10.1038/ni986 . 13016860 .
• Oshiumi H, Sasai M, Shida K, etal . TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta . J. Biol. Chem. . 278 . 50 . 49751–62 . 2004 . 14519765 . 10.1074/jbc.M305820200 . free.
• Fitzgerald KA, Rowe DC, Barnes BJ, etal . LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF . J. Exp. Med. . 198 . 7 . 1043–55 . 2003 . 14517278 . 10.1084/jem.20031023 . 2194210 .
• Matsuda A, Suzuki Y, Honda G, etal . Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways . Oncogene . 22 . 21 . 3307–18 . 2003 . 12761501 . 10.1038/sj.onc.1206406 . 38880905 .
• Bin LH, Xu LG, Shu HB . TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling . J. Biol. Chem. . 278 . 27 . 24526–32 . 2003 . 12721283 . 10.1074/jbc.M303451200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lai CH, Chou CY, Ch'ang LY, etal . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Res. . 10 . 5 . 703–13 . 2000 . 10810093 . 10.1101/gr.10.5.703 . 310876 .

Notes and References

1. Web site: Entrez Gene: TICAM2 toll-like receptor adaptor molecule 2.
2. Web site: Entrez Gene: TICAM2 toll-like receptor adaptor molecule 2.