TIAF1 explained

TGFB1-induced anti-apoptotic factor 1 is a protein that in humans is encoded by the TIAF1 gene.^{[1] [2]}

Interactions

TIAF1 has been shown to interact with Janus kinase 3^[3] and TRIB3.^[4]

Further reading

• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain . DNA Research . 3 . 5 . 321–9, 341-54 . October 1996 . 9039502 . 10.1093/dnares/3.5.321 . free .
• Ji H, Zhai Q, Zhu J, Yan M, Sun L, Liu X, Zheng Z . A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival . Biochemical and Biophysical Research Communications . 270 . 1 . 267–71 . April 2000 . 10733938 . 10.1006/bbrc.2000.2413 .
• Mori K, Furusawa T, Okubo T, Inoue T, Ikawa S, Yanai N, Mori KJ, Obinata M . Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A) . Journal of Biochemistry . 133 . 4 . 405–13 . April 2003 . 12761286 . 10.1093/jb/mvg053 .
• van der Leij J, van den Berg A, Albrecht EW, Blokzijl T, Roozendaal R, Gouw AS, de Jong KP, Stegeman CA, van Goor H, Chang NS, Poppema S . High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells . Transplantation . 75 . 12 . 2076–82 . June 2003 . 12829915 . 10.1097/01.TP.0000069829.71088.88 . 24178625 . free .
• Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G . Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network . The Journal of Biological Chemistry . 279 . 13 . 12804–11 . March 2004 . 14676191 . 10.1074/jbc.M312171200 . free .
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nature Cell Biology . 6 . 2 . 97–105 . February 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Schultz L, Khera S, Sleve D, Heath J, Chang NS . TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53 . DNA and Cell Biology . 23 . 1 . 67–74 . January 2004 . 14965474 . 10.1089/104454904322745943 .
• Homma K, Kikuno RF, Nagase T, Ohara O, Nishikawa K . Alternative splice variants encoding unstable protein domains exist in the human brain . Journal of Molecular Biology . 343 . 5 . 1207–20 . November 2004 . 15491607 . 10.1016/j.jmb.2004.09.028 .
• Isogawa Y, Kon T, Inoue T, Ohkura R, Yamakawa H, Ohara O, Sutoh K . The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site . Biochemistry . 44 . 16 . 6190–6 . April 2005 . 15835906 . 10.1021/bi0475931 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Chang NS, Mattison J, Cao H, Pratt N, Zhao Y, Lee C . Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity . Biochemical and Biophysical Research Communications . 253 . 3 . 743–9 . December 1998 . 9918798 . 10.1006/bbrc.1998.9846 .
2. Web site: Entrez Gene: TIAF1 TGFB1-induced anti-apoptotic factor 1.
3. Ji H, Zhai Q, Zhu J, Yan M, Sun L, Liu X, Zheng Z . A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival . Biochemical and Biophysical Research Communications . 270 . 1 . 267–71 . April 2000 . 10733938 . 10.1006/bbrc.2000.2413 .
4. Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F . E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3 . Cellular Signalling . 20 . 5 . 942–8 . May 2008 . 18276110 . 10.1016/j.cellsig.2008.01.010 .