THSD1 explained

Thrombospondin type-1 domain-containing protein 1 is a protein that in humans is encoded by the THSD1 gene.^[1]

The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in thrombospondin, a number of proteins involved in the complement pathway, as well as extracellular matrix proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Further reading

• Bork P . The modular architecture of a new family of growth regulators related to connective tissue growth factor . FEBS Lett. . 327 . 2 . 125–30 . 1993 . 7687569 . 10.1016/0014-5793(93)80155-N . free .
• Gruber HE, Ingram JA, Hanley EN . Immunolocalization of thrombospondin in the human and sand rat intervertebral disc . Spine . 31 . 22 . 2556–61 . 2007 . 17047544 . 10.1097/01.brs.0000241117.31510.e3 . 43521262 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE . Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly . J. Biol. Chem. . 279 . 47 . 48983–92 . 2005 . 15371459 . 10.1074/jbc.M404881200 . free .
• Dunham A . The DNA sequence and analysis of human chromosome 13 . Nature . 428 . 6982 . 522–8 . 2004 . 15057823 . 10.1038/nature02379 . 2665288 . vanc. Matthews LH . Burton J . 3 . Ashurst . J. L. . Howe . K. L. . Ashcroft . K. J. . Beare . D. M. . Burford . D. C. . Hunt . S. E. . 2004Natur.428..522D .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Clark HF . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . vanc. Gurney AL . Abaya E . 3 . Baker . K . Baldwin . D . Brush . J . Chen . J . Chow . B . Chui . C .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .

Notes and References

1. Web site: Entrez Gene: THSD1 thrombospondin, type I, domain containing 1.