THRSP explained

Thyroid hormone-inducible hepatic protein is a protein that in humans is encoded by the THRSP gene.^{[1] [2]}

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors.

This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.

Previously, THRSP was among the identified upregulated genes in the prefrontal cortex of spontaneously hypertensive rats (SHR/NCrl) and Wistar-Kyoto (WKY/NCrl) rats which exhibited inattention behavior.^[3] Subsequently, overexpression of THRSP induced inattention, but not hyperactive and impulsive behavior in mice, suggesting that this gene plays a role in the inattention phenotype of ADHD.^[4]

Further reading

• Cunningham BA, Moncur JT, Huntington JT, Kinlaw WB . "Spot 14" protein: a metabolic integrator in normal and neoplastic cells. . Thyroid . 8 . 9 . 815–25 . 1998 . 9777755 . 10.1089/thy.1998.8.815 .
• Ota Y, Mariash A, Wagner JL, Mariash CN . Cloning, expression and regulation of the human S14 gene. . Mol. Cell. Endocrinol. . 126 . 1 . 75–81 . 1997 . 9027365 . 10.1016/S0303-7207(96)03971-8 . 22056127 .
• Taviaux S . Assignment of thyroid hormone responsive SPOT 14 homolog (THRSP) to human chromosome 11 bands q13.5→q14.1 by in situ hybridization . Cytogenet. Cell Genet. . 76 . 3–4 . 219–20 . 1997 . 9186528 . 10.1159/000134553 . vanc. Planells R . Gastaldi M . 3 . Torresani . J. . Grillasca . J.P. .
• Moncur JT . Assignment of the "spot 14" gene (THRSP) to human chromosome band 11q13.5 by in situ hybridization . Cytogenet. Cell Genet. . 78 . 2 . 131–2 . 1997 . 9371405 . 10.1159/000134644 . vanc. Park JP . Maloney M . 3 . Mohandas . T.K. . Kinlaw . W.B. .
• Cunningham BA, Maloney M, Kinlaw WB . Spot 14 protein-protein interactions: evidence for both homo- and heterodimer formation in vivo . Endocrinology . 138 . 12 . 5184–8 . 1997 . 9389499 . 10.1210/en.138.12.5184 . free .
• Moncur JT . The "Spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism . Proc. Natl. Acad. Sci. U.S.A. . 95 . 12 . 6989–94 . 1998 . 9618526 . 10.1073/pnas.95.12.6989 . 22712 . vanc. Park JP . Memoli VA . 3 . Mohandas . TK . Kinlaw . WB . 1998PNAS...95.6989M . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Campbell MC, Anderson GW, Mariash CN . Human spot 14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification . Endocrinology . 144 . 12 . 5242–8 . 2004 . 12960053 . 10.1210/en.2002-0008 . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Chou WY . Human spot 14 protein interacts physically and functionally with the thyroid receptor . Biochem. Biophys. Res. Commun. . 357 . 1 . 133–8 . 2007 . 17418816 . 10.1016/j.bbrc.2007.03.103 . vanc. Cheng YS . Ho CL . 3 . Liu . Shu-Ting . Liu . Pei-Yao . Kuo . Chen-Chin . Chang . Hui-Ping . Chen . Yu-Hou . Chang . Gu-Gang .

Notes and References

1. Grillasca JP, Gastaldi M, Khiri H, Dace A, Peyrol N, Reynier P, Torresani J, Planells R . Cloning and initial characterization of human and mouse Spot 14 genes . FEBS Lett . 401 . 1 . 38–42 . Feb 1997 . 9003802 . 10.1016/S0014-5793(96)01433-0 . 44575293 . free .
2. Web site: Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat).
3. dela Peña. Ike. Bang. Minji. Lee. Jinhee. de la Peña. June Bryan. Kim. Bung-Nyun. Han. Doug Hyun. Noh. Minsoo. Shin. Chan Young. Cheong. Jae Hoon. September 2015. Common prefrontal cortical gene expression profiles between adolescent SHR/NCrl and WKY/NCrl rats which showed inattention behavior. Behavioural Brain Research. en. 291. 268–276. 10.1016/j.bbr.2015.05.012. 26048425. 9853684.
4. Custodio. Raly James Perez. Botanas. Chrislean Jun. de la Peña. June Bryan. dela Peña. Irene Joy. Kim. Mikyung. Sayson. Leandro Val. Abiero. Arvie. Ryoo. Zae Young. Kim. Bung-Nyun. Kim. Hee Jin. Cheong. Jae Hoon. October 2018. Overexpression of the Thyroid Hormone-Responsive (THRSP) Gene in the Striatum Leads to the Development of Inattentive-like Phenotype in Mice. Neuroscience. en. 390. 141–150. 10.1016/j.neuroscience.2018.08.008. 30138648. 52075574.