THOP1 explained

Thimet oligopeptidase is an enzyme that in humans is encoded by the THOP1 gene.^{[1] [2]}

Further reading

• Thompson A, Huber G, Malherbe P . Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide. . Biochem. Biophys. Res. Commun. . 213 . 1 . 66–73 . 1995 . 7639763 . 10.1006/bbrc.1995.2099 .
• Papastoitsis G, Siman R, Scott R, Abraham CR . Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. . Biochemistry . 33 . 1 . 192–9 . 1994 . 8286339 . 10.1021/bi00167a025 .
• Dando PM, Brown MA, Barrett AJ . Human thimet oligopeptidase . Biochem. J. . 294 . Pt 2. 451–7 . 1993 . 8373360 . 10.1042/bj2940451. 1134475 .
• Meckelein B . Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus . Genomics . 31 . 2 . 246–9 . 1997 . 8824811 . 10.1006/geno.1996.0041 . vanc. de Silva HA . Roses AD . 3 . Rao . P.Nagesh . Pettenati . Mark J. . Xu . Pu-Ting . Hodge . Rosa . Glucksman . Marc J. . Abraham . Carmela R. . free .
• Crack PJ . The association of metalloendopeptidase EC 3.4.24.15 at the extracellular surface of the AtT-20 cell plasma membrane . Brain Res. . 835 . 2 . 113–24 . 1999 . 10415366 . 10.1016/S0006-8993(99)01494-8 . vanc. Wu TJ . Cummins PM . 3 . Ferro . Emer S . Tullai . John W . Glucksman . Marc J . Roberts . James L . 23769423 .
• Pineau C . Distribution of thimet oligopeptidase (E.C. 3.4.24.15) in human and rat testes . J. Cell Sci. . 112 . 20. 3455–62 . 2000 . 10504294 . vanc. McCool S . Glucksman MJ . 3 . Jégou . B . Pierotti . AR . 10.1242/jcs.112.20.3455 .
• Ferro ES, Tullai JW, Glucksman MJ, Roberts JL . Secretion of metalloendopeptidase 24.15 (EC 3.4.24.15) . DNA Cell Biol. . 18 . 10 . 781–9 . 1999 . 10541437 . 10.1089/104454999314926 . 11449/37910 . free .
• Tullai JW . The neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylation . J. Biol. Chem. . 275 . 47 . 36514–22 . 2001 . 10969067 . 10.1074/jbc.M001843200 . vanc. Cummins PM . Pabon A . 3 . Roberts . JL . Lopingco . MC . Shrimpton . CN . Smith . AI . Martignetti . JA . Ferro . ES . free .
• Molina HM, Carmona AK, Kouyoumdjian M, Borges DR . Thimet oligopeptidase EC 3.4.24.15 is a major liver kininase . Life Sci. . 67 . 5 . 509–20 . 2000 . 10993116 . 10.1016/S0024-3205(00)00650-0 .
• Saric T . Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase . J. Biol. Chem. . 276 . 39 . 36474–81 . 2001 . 11479311 . 10.1074/jbc.M105517200 . vanc. Beninga J . Graef CI . 3 . Akopian . TN . Rock . KL . Goldberg . AL . free.
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gioli-Pereira L, Fontenele-Neto JD, Borges DR, Kouyoumdjian M . Localization of EP24.15, a major liver kininase . J. Histochem. Cytochem. . 51 . 1 . 125–7 . 2003 . 12502762 . 10.1177/002215540305100115 . free .
• York IA . The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation . Immunity . 18 . 3 . 429–40 . 2003 . 12648459 . 10.1016/S1074-7613(03)00058-X . vanc. Mo AX . Lemerise K . 3 . Zeng . Wanyong . Shen . Yuelei . Abraham . Carmela R. . Saric . Tomo . Goldberg . Alfred L. . Rock . Kenneth L. . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Ray K, Hines CS, Coll-Rodriguez J, Rodgers DW . Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization . J. Biol. Chem. . 279 . 19 . 20480–9 . 2004 . 14998993 . 10.1074/jbc.M400795200 . free .
• Grimwood J . The DNA sequence and biology of human chromosome 19 . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . vanc. Gordon LA . Olsen A . 3 . Terry . Astrid . Schmutz . Jeremy . Lamerdin . Jane . Hellsten . Uffe . Goodstein . David . Couronne . Olivier . 2004Natur.428..529G . free .
• Lehner B, Sanderson CM . A Protein Interaction Framework for Human mRNA Degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Saric T, Graef CI, Goldberg AL . Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases . J. Biol. Chem. . 279 . 45 . 46723–32 . 2004 . 15328361 . 10.1074/jbc.M406537200 . free .
• Shivakumar BR, Wang Z, Hammond TG, Harris RC . EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor . Cell Biochem. Funct. . 23 . 3 . 195–204 . 2005 . 15376229 . 10.1002/cbf.1176 . 5695331 .

Notes and References

1. Torres MP, Prange C, Lennon G . Human endopeptidase 24.15 (THOP1) is localized on chromosome 19p13.3 and is excluded from the linkage region for late-onset Alzheimer disease . Genomics . 53 . 2 . 239–40 . Dec 1998 . 9790774 . 10.1006/geno.1998.5487 .
2. Web site: Entrez Gene: THOP1 thimet oligopeptidase 1.