THOC1 explained

THO complex subunit 1 is a protein that in humans is encoded by the THOC1 gene.^{[1] [2]}

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM]^[2]

Interactions

THOC1 has been shown to interact with Retinoblastoma protein.^[3]

Further reading

• Durfee T, Mancini MA, Jones D, etal . The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. . J. Cell Biol. . 127 . 3 . 609–22 . 1994 . 7525595 . 10.1083/jcb.127.3.609 . 2120229 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Dennehey BK, Gutches DG, McConkey EH, Krauter KS . Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution. . Genomics . 83 . 3 . 493–501 . 2004 . 14962675 . 10.1016/j.ygeno.2003.08.017 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Gasparri F, Sola F, Locatelli G, Muzio M . The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm. . FEBS Lett. . 574 . 1–3 . 13–9 . 2004 . 15358532 . 10.1016/j.febslet.2004.07.074 . 43023236 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Li Y, Wang X, Zhang X, Goodrich DW . Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. . Mol. Cell. Biol. . 25 . 10 . 4023–33 . 2005 . 15870275 . 10.1128/MCB.25.10.4023-4033.2005 . 1087710 .
• Masuda S, Das R, Cheng H, etal . Recruitment of the human TREX complex to mRNA during splicing. . Genes Dev. . 19 . 13 . 1512–7 . 2005 . 15998806 . 10.1101/gad.1302205 . 1172058 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Li Y, Lin AW, Zhang X, etal . Cancer cells and normal cells differ in their requirements for Thoc1. . Cancer Res. . 67 . 14 . 6657–64 . 2007 . 17638875 . 10.1158/0008-5472.CAN-06-3234 . 2804983 .
• Garner E, Martinon F, Tschopp J, etal . Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6. . Cancer Res. . 67 . 16 . 7631–7 . 2007 . 17699767 . 10.1158/0008-5472.CAN-07-0334 . free .

Notes and References

1. Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E . TREX is a conserved complex coupling transcription with messenger RNA export . Nature . 417 . 6886 . 304–8 . May 2002 . 11979277 . 10.1038/nature746 . 2002Natur.417..304S . 1112194 .
2. Web site: Entrez Gene: THOC1 THO complex 1.
3. Durfee . T . Mancini M A . Jones D . Elledge S J . Lee W H . November 1994 . The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing . J. Cell Biol. . 127 . 3 . 609–22 . 0021-9525. 7525595 . 10.1083/jcb.127.3.609 . 2120229 .