TH-PVP explained

TH-PVP is a substituted cathinone derivative which has been sold as a designer drug. It was first identified by a forensic laboratory in Hungary in 2015,^[1] but has subsequently been found in numerous other countries around the world including Spain, Belgium, Poland, Turkey and Brazil.^{[2] [3] [4] [5] [6] [7]} Pharmacological studies in vitro showed it to inhibit reuptake and promote the release of monoamine neurotransmitters with some selectivity for serotonin,^[8] but it failed to produce stimulant effects in animals,^[9] and has a pharmacological profile more comparable to that of sedating empathogens such as MDAI and 5-Methyl-MDA.

See also

• 3,4-Pr-PipVP
• 3-Me-PVP
• 4-Et-PVP
• 5-BPDi
• 6-APT
• EDMA
• Indapyrophenidone
• Naphyrone
• O-2390

Notes and References

1. Web site: EMCDDA–Europol 2015 Annual Report on the implementation of Council Decision 2005/387/JHA . 2019-12-08 . 2020-11-08 . https://web.archive.org/web/20201108073052/https://www.emcdda.europa.eu/system/files/publications/2880/TDAS16001ENN.pdf . live .
2. Nycz JE, Pazdziorek T, Malecki G, Szala M . Identification and derivatization of selected cathinones by spectroscopic studies . Forensic Science International . 266 . 416–426 . September 2016 . 27423024 . 10.1016/j.forsciint.2016.06.034 .
3. Yanini A, Esteve-Turrillas FA, de la Guardia M, Armenta S . Ion mobility spectrometry and high resolution mass-spectrometry as methodologies for rapid identification of the last generation of new psychoactive substances . Journal of Chromatography A . 1574 . 91–100 . November 2018 . 30220430 . 10.1016/j.chroma.2018.09.006 . 52281842 .
4. Wille SM, Richeval C, Nachon-Phanithavong M, Gaulier JM, Di Fazio V, Humbert L, Samyn N, Allorge D . Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population . Drug Testing and Analysis . 10 . 3 . 539–547 . March 2018 . 28640970 . 10.1002/dta.2232 .
5. Błażewicz A, Bednarek E, Popławska M, Olech N, Sitkowski J, Kozerski L . Identification and structural characterization of synthetic cathinones: N-propylcathinone, 2,4-dimethylmethcathinone, 2,4-dimethylethcathinone, 2,4-dimethyl-α-pyrrolidinopropiophenone, 4-bromo-α-pyrrolidinopropiophenone, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one and 2,4-dimethylisocathinone. . Forensic Toxicol . July 2019 . 37 . 2 . 288–307 . 10.1007/s11419-018-00463-w . free .
6. Göl E, Çok I . New psychoactive substances in Turkey: Narcotics cases assessed by the Council of Forensic Medicine between 2016 and 2017 in Ankara, Turkey . Forensic Science International . 294 . 113–123 . January 2019 . 30502695 . 10.1016/j.forsciint.2018.11.003 . 56176934 .
7. Boff B, Silveira Filho J, Nonemacher K, Schroeder SD, Arbo MD . New psychoactive substances (NPS) prevalence over LSD in blotter seized in State of Santa Catarina, Brazil: a six-year retrospective study. . Forensic Science International . 24 October 2019 . 306 . 110002 . 10.1016/j.forsciint.2019.110002 . 31864775 . 208415740 .
8. Eshleman AJ, Nagarajan S, Wolfrum KM, Reed JF, Swanson TL, Nilsen A, Janowsky A . Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters . Psychopharmacology . 236 . 3 . 939–952 . March 2019 . 30397775 . 10.1007/s00213-018-5059-5 . 6500773 .
9. Gatch MB, Dolan SB, Forster MJ . Locomotor activity and discriminative stimulus effects of five novel synthetic cathinone analogs in mice and rats . Drug and Alcohol Dependence . 199 . 50–58 . June 2019 . 30986635 . 10.1016/j.drugalcdep.2019.02.016 . 6534427 .