TGS1 explained

Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene.^{[1] [2] [3]}

Interactions

TGS1 has been shown to interact with:

• CREB-binding protein, and
• EED,^[4]
• EP300,
• MED1, and
• NCOA6.^[5]

Further reading

• Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK . Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation . J. Biol. Chem. . 277 . 22 . 20011–9 . 2002 . 11912212 . 10.1074/jbc.M201739200 . free.
• Verheggen C, Lafontaine DL, Samarsky D, Mouaikel J, Blanchard JM, Bordonné R, Bertrand E . Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments . EMBO J. . 21 . 11 . 2736–45 . 2002 . 12032086 . 126019 . 10.1093/emboj/21.11.2736 .
• Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF . Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies . J. Immunol. . 169 . 2 . 1102–9 . 2002 . 12097419 . 10.4049/jimmunol.169.2.1102 . free .
• Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi AV, Kashireddy P, Cherkaoui-Malki M, Qi C, Zhu YJ, Rao MS, Reddy JK . Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator . Proc. Natl. Acad. Sci. U.S.A. . 99 . 18 . 11836–41 . 2002 . 12189208 . 129355 . 10.1073/pnas.182426699 . 2002PNAS...9911836S . free .
• Krackhardt AM, Witzens M, Harig S, Hodi FS, Zauls AJ, Chessia M, Barrett P, Gribben JG . Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX . Blood . 100 . 6 . 2123–31 . 2002 . 12200376 . 10.1182/blood-2002-02-0513 . free .
• Mouaikel J, Narayanan U, Verheggen C, Matera AG, Bertrand E, Tazi J, Bordonné R . Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron . EMBO Rep. . 4 . 6 . 616–22 . 2004 . 12776181 . 1319203 . 10.1038/sj.embor.embor863 .
• Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I . Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus . Biochem. Biophys. Res. Commun. . 309 . 1 . 44–51 . 2003 . 12943661 . 10.1016/S0006-291X(03)01514-6 .
• Watkins NJ, Lemm I, Ingelfinger D, Schneider C, Hossbach M, Urlaub H, Lührmann R . Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex . Mol. Cell . 16 . 5 . 789–98 . 2005 . 15574333 . 10.1016/j.molcel.2004.11.012 . 11858/00-001M-0000-0012-EB89-8 . free .
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS . Transcriptome analysis of human gastric cancer . Mamm. Genome . 16 . 12 . 942–54 . 2006 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 .

Notes and References

1. Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK . Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function . Proc Natl Acad Sci U S A . 98 . 18 . 10380–5 . Aug 2001 . 11517327 . 56969 . 10.1073/pnas.181347498 . 2001PNAS...9810380Z . free .
2. Mouaikel J, Verheggen C, Bertrand E, Tazi J, Bordonné R . Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus . Mol Cell . 9 . 4 . 891–901 . May 2002 . 11983179 . 10.1016/S1097-2765(02)00484-7 . free .
3. Web site: Entrez Gene: TGS1 trimethylguanosine synthase homolog (S. cerevisiae).
4. Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I . Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus . Biochem. Biophys. Res. Commun. . 309 . 1 . 44–51 . Sep 2003 . 12943661 . 10.1016/s0006-291x(03)01514-6.
5. Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK . Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation . J. Biol. Chem. . 277 . 22 . 20011–9 . May 2002 . 11912212 . 10.1074/jbc.M201739200 . free.