TFPI2 explained

Tissue factor pathway inhibitor 2 is a protein that in humans is encoded by the TFPI2 gene.^{[1] [2] [3]}

Further reading

• Bützow R . Purification and characterization of placental protein 5 . Biochem. Biophys. Res. Commun. . 150 . 1 . 483–90 . 1988 . 3276312 . 10.1016/0006-291X(88)90546-3 . vanc. Huhtala ML . Bohn H . 3 . Virtanen . Ismo . Seppälä . Markku .
• Takayama M . Circulating levels of placental protein 5 in normal and abnormal pregnancies . Gynecol. Obstet. Invest. . 16 . 1 . 13–26 . 1983 . 6884838 . 10.1159/000299207 . vanc. Soma H . Saito T . 3 . Isaka . K. . Kashiwagi . H. . Ogawa . T. . Suzuki . Y. . Sayama . S. .
• Sprecher CA, Kisiel W, Mathewes S, Foster DC . Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor . Proc. Natl. Acad. Sci. U.S.A. . 91 . 8 . 3353–7 . 1994 . 8159751 . 10.1073/pnas.91.8.3353 . 43575 . 1994PNAS...91.3353S . free .
• Petersen LC . Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor . Biochemistry . 35 . 1 . 266–72 . 1996 . 8555184 . 10.1021/bi951501d . vanc. Sprecher CA . Foster DC . 3 . Blumberg . Hal . Hamamoto . Takayoshi . Kisiel . Walter .
• Miyagi Y . Assignment of the human PP5/TFPI-2 gene to 7q22 by FISH and PCR-based human/rodent cell hybrid mapping panel analysis . Genomics . 35 . 1 . 267–8 . 1996 . 8661135 . 10.1006/geno.1996.0353 . vanc. Yasumitsu H . Eki T . 3 . Miyata . Satoshi . Kkawa . Naohiko . Hirahara . Fumiki . Aoki . Ichiro . Misugi . Kazuaki . Miyazaki . Kaoru .
• Rao CN . Extracellular matrix-associated serine protease inhibitors (Mr 33,000, 31,000, and 27,000) are single-gene products with differential glycosylation: cDNA cloning of the 33-kDa inhibitor reveals its identity to tissue factor pathway inhibitor-2 . Arch. Biochem. Biophys. . 335 . 1 . 82–92 . 1996 . 8914837 . 10.1006/abbi.1996.0484 . vanc. Reddy P . Liu Y . 3 . O'Toole . E . Reeder . D . Foster . DC . Kisiel . W . Woodley . DT .
• Iino M, Foster DC, Kisiel W . Quantification and characterization of human endothelial cell-derived tissue factor pathway inhibitor-2 . Arterioscler. Thromb. Vasc. Biol. . 18 . 1 . 40–6 . 1998 . 9445254 . 10.1161/01.ATV.18.1.40 . free .
• Udagawa K . Specific expression of PP5/TFPI2 mRNA by syncytiotrophoblasts in human placenta as revealed by in situ hybridization . Placenta . 19 . 2–3 . 217–23 . 1998 . 9548189 . 10.1016/S0143-4004(98)90011-X . vanc. Miyagi Y . Hirahara F . 3 . Miyagi . E. . Nagashima . Y. . Minaguchi . H. . Misugi . K. . Yasumitsu . H. . Miyazaki . K. .
• Shinoda E . Tissue factor pathway inhibitor-2 is a novel mitogen for vascular smooth muscle cells . J. Biol. Chem. . 274 . 9 . 5379–84 . 1999 . 10026147 . 10.1074/jbc.274.9.5379 . vanc. Yui Y . Hattori R . 3 . Tanaka . M . Inoue . R . Aoyama . T . Takimoto . Y . Mitsui . Y . Miyahara . K . free . 2433/181716 . free .
• Liu Y . Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plasmin . Arch. Biochem. Biophys. . 370 . 1 . 112–8 . 1999 . 10496984 . 10.1006/abbi.1999.1371 . vanc. Stack SM . Lakka SS . 3 . Khan . AJ . Woodley . DT . Rao . JS . Rao . CN .
• Kamei S . Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene . Biochim. Biophys. Acta . 1517 . 3 . 430–5 . 2001 . 11342222 . 10.1016/S0167-4781(00)00298-0. vanc. Kazama Y . Kuijper JL . 3 . Foster . DC . Kisiel . W .
• Crawley JT . Expression and localization of tissue factor pathway inhibitor-2 in normal and atherosclerotic human vessels . Arterioscler. Thromb. Vasc. Biol. . 22 . 2 . 218–24 . 2002 . 11834519 . 10.1161/hq0102.101842 . vanc. Goulding DA . Ferreira V . 3 . Severs . NJ . Lupu . F . free.
• Konduri SD . Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas . Oncogene . 21 . 6 . 921–8 . 2002 . 11840337 . 10.1038/sj.onc.1204983 . vanc. Osman FA . Rao CN . 3 . Srinivas . Harish . Yanamandra . Niranjan . Tasiou . Anastasia . Dinh . Dzung H . Olivero . William C . Gujrati . Meena . free .
• Udagawa K . Subcellular localization of PP5/TFPI-2 in human placenta: a possible role of PP5/TFPI-2 as an anti-coagulant on the surface of syncytiotrophoblasts . Placenta . 23 . 2–3 . 145–53 . 2002 . 11945080 . 10.1053/plac.2001.0774 . vanc. Yasumitsu H . Esaki M . 3 . Sawada . H. . Nagashima . Y. . Aoki . I. . Jin . M. . Miyagi . E. . Nakazawa . T. .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Hubé F . Demonstration of a tissue factor pathway inhibitor 2 messenger RNA synthesis by pure villous cytotrophoblast cells isolated from term human placentas . Biol. Reprod. . 68 . 5 . 1888–94 . 2003 . 12606321 . 10.1095/biolreprod.102.011858 . vanc. Reverdiau P . Iochmann S . 3 . Trassard . S . Thibault . G . Gruel . Y . 32145819 . free.
• George J, Gondi CS, Dinh DH, Gujrati M, Rao JS . Restoration of TFPI-2 in a Human Glioblastoma Cell Line Triggers Caspase Mediated Pathway and Apoptosis . Clin. Cancer Res. . 13. 12 . 3507–3517 . 2007 . 17575213 . 10.1158/1078-0432.CCR-06-3023 . 1905856 .
• Rao CN . Methylation of TFPI-2 gene is not the sole cause of its silencing . Int. J. Oncol. . 22 . 4 . 843–8 . 2003 . 12632077 . 10.3892/ijo.22.4.843. vanc. Segawa T . Navari JR . 3 . Xu . L . Srivastava . S . Moul . JW . Phillips . B .
• Scherer SW . Human Chromosome 7: DNA Sequence and Biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . vanc. Cheung J . MacDonald JR . 3 . Osborne . LR . Nakabayashi . K . Herbrick . JA . Carson . AR . Parker-Katiraee . L . Skaug . J . 2003Sci...300..767S .

Notes and References

1. Miyagi Y, Koshikawa N, Yasumitsu H, Miyagi E, Hirahara F, Aoki I, Misugi K, Umeda M, Miyazaki K . cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2 . J Biochem . 116 . 5 . 939–42 . Apr 1995 . 7896752 . 10.1093/oxfordjournals.jbchem.a124648.
2. Miyagi Y, Yasumitsu H, Mizushima H, Koshikawa N, Matsuda Y, Itoh H, Hori TA, Aoki I, Misugi K, Miyazaki K . Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6 . DNA Cell Biol . 15 . 11 . 947–54 . Jan 1997 . 8945635 . 10.1089/dna.1996.15.947 .
3. Web site: Entrez Gene: TFPI2 tissue factor pathway inhibitor 2.