TFDP2 explained

Transcription factor Dp-2 is a protein that in humans is encoded by the TFDP2 gene that dimerises with E2F, a key transcriptional activator involved in the regulation of the cell cycle.^{[1] [2] [3]}

Further reading

• Wu CL, Zukerberg LR, Ngwu C, etal . In vivo association of E2F and DP family proteins . Mol. Cell. Biol. . 15 . 5 . 2536–46 . 1995 . 7739537 . 10.1128/mcb.15.5.2536. 230484 .
• Rogers KT, Higgins PD, Milla MM, etal . DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo . Proc. Natl. Acad. Sci. U.S.A. . 93 . 15 . 7594–9 . 1996 . 8755520 . 10.1073/pnas.93.15.7594 . 38791 . 1996PNAS...93.7594R . free .
• Loiseau L, Pasteau S, Brun G . Molecular cloning and expression pattern of the DP members of the chicken E2F transcription factor . Gene Expr. . 6 . 5 . 259–73 . 1998 . 9368098 . 6148286 .
• Trimarchi JM, Fairchild B, Verona R, etal . E2F-6, a member of the E2F family that can behave as a transcriptional repressor . Proc. Natl. Acad. Sci. U.S.A. . 95 . 6 . 2850–5 . 1998 . 9501179 . 10.1073/pnas.95.6.2850 . 19658 . 1998PNAS...95.2850T . free .
• Gaubatz S, Wood JG, Livingston DM . Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6 . Proc. Natl. Acad. Sci. U.S.A. . 95 . 16 . 9190–5 . 1998 . 9689056 . 10.1073/pnas.95.16.9190 . 21314 . 1998PNAS...95.9190G . free .
• Zheng N, Fraenkel E, Pabo CO, Pavletich NP . Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F–DP . Genes Dev. . 13 . 6 . 666–74 . 1999 . 10090723 . 10.1101/gad.13.6.666 . 316551 .
• Korz C, Pscherer A, Benner A, etal . Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes . Blood . 99 . 12 . 4554–61 . 2002 . 12036888 . 10.1182/blood.V99.12.4554 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Park KK, Deok Ahn J, Lee IK, etal . Inhibitory effects of novel E2F decoy oligodeoxynucleotides on mesangial cell proliferation by coexpression of E2F/DP . Biochem. Biophys. Res. Commun. . 308 . 4 . 689–97 . 2003 . 12927774 . 10.1016/S0006-291X(03)01455-4 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Zhang Y, Chellappan SP . Cloning and characterization of human DP2, a novel dimerization partner of E2F . Oncogene . 10 . 11 . 2085–93 . Jul 1995 . 7784053 .
2. Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP . Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family . Genomics . 39 . 1 . 95–8 . Mar 1997 . 9027491 . 10.1006/geno.1996.4473 .
3. Web site: Entrez Gene: TFDP2 transcription factor Dp-2 (E2F dimerization partner 2).