TFDP1 explained

Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.^{[1] [2] [3]}

Function

The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors; see TFDP2 (MIM 602160).[supplied by OMIM]

Interactions

TFDP1 has been shown to interact with:

• E2F1,^{[4] [5] [6] [7]}
• E2F5,^{[4] [8]} and
• P53.^[9]

Further reading

• Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA . In vivo association of E2F and DP family proteins. . Mol. Cell. Biol. . 15 . 5 . 2536–46 . 1995 . 7739537 . 230484 . 10.1128/mcb.15.5.2536.
• Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R . E2F-5, a new E2F family member that interacts with p130 in vivo. . Mol. Cell. Biol. . 15 . 6 . 3082–9 . 1995 . 7760804 . 230539 . 10.1128/mcb.15.6.3082.
• Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA . E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. . Proc. Natl. Acad. Sci. U.S.A. . 92 . 6 . 2403–7 . 1995 . 7892279 . 42492 . 10.1073/pnas.92.6.2403 . 1995PNAS...92.2403S . free .
• Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM . E2F-4, a new member of the E2F transcription factor family, interacts with p107. . Genes Dev. . 8 . 22 . 2665–79 . 1994 . 7958924 . 10.1101/gad.8.22.2665 . free .
• Beijersbergen RL, Kerkhoven RM, Zhu L, Carlée L, Voorhoeve PM, Bernards R . E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. . Genes Dev. . 8 . 22 . 2680–90 . 1994 . 7958925 . 10.1101/gad.8.22.2680 . free .
• Bandara LR, Lam EW, Sørensen TS, Zamanian M, Girling R, La Thangue NB . DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. . EMBO J. . 13 . 13 . 3104–14 . 1994 . 8039504 . 395201 . 10.1002/j.1460-2075.1994.tb06609.x.
• Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E . Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. . Genes Dev. . 7 . 10 . 1850–61 . 1993 . 8405995 . 10.1101/gad.7.10.1850 . free .
• Rogers KT, Higgins PD, Milla MM, Phillips RS, Horowitz JM . DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. . Proc. Natl. Acad. Sci. U.S.A. . 93 . 15 . 7594–9 . 1996 . 8755520 . 38791 . 10.1073/pnas.93.15.7594 . 1996PNAS...93.7594R . free .
• Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB . Functional interaction between DP-1 and p53. . Mol. Cell. Biol. . 16 . 10 . 5888–95 . 1996 . 8816502 . 231590 . 10.1128/mcb.16.10.5888.
• Vidal M, Braun P, Chen E, Boeke JD, Harlow E . Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system. . Proc. Natl. Acad. Sci. U.S.A. . 93 . 19 . 10321–6 . 1996 . 8816798 . 38382 . 10.1073/pnas.93.19.10321 . 1996PNAS...9310321V . free .
• Magae J, Wu CL, Illenye S, Harlow E, Heintz NH . Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. . J. Cell Sci. . (Pt 7) . 1717–26 . 1997 . 8832394 . 109 . 7 . 10.1242/jcs.109.7.1717 .
• Hofmann F, Livingston DM . Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. . Genes Dev. . 10 . 7 . 851–61 . 1996 . 8846921 . 10.1101/gad.10.7.851 . free .
• Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA . E2F-6, a member of the E2F family that can behave as a transcriptional repressor. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 6 . 2850–5 . 1998 . 9501179 . 19658 . 10.1073/pnas.95.6.2850 . 1998PNAS...95.2850T . free .
• Cartwright P, Müller H, Wagener C, Holm K, Helin K . E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription. . Oncogene . 17 . 5 . 611–23 . 1998 . 9704927 . 10.1038/sj.onc.1201975 . 7688110 .
• Timchenko NA, Wilde M, Darlington GJ . C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. . Mol. Cell. Biol. . 19 . 4 . 2936–45 . 1999 . 10082561 . 84088 . 10.1128/mcb.19.4.2936.
• Lam EW, Glassford J, van der Sman J, Banerji L, Pizzey AR, Shaun N, Thomas B, Klaus GG . Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors. . Eur. J. Immunol. . 29 . 10 . 3380–9 . 1999 . 10540350 . 10.1002/(SICI)1521-4141(199910)29:10<3380::AID-IMMU3380>3.0.CO;2-C . free .
• Sansal I, Dupont E, Toru D, Evrard C, Rouget P . NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity. . Oncogene . 19 . 43 . 5000–9 . 2000 . 11042687 . 10.1038/sj.onc.1203843 . 41370242 .
• Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E, Bonventre JV . TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. . EMBO J. . 20 . 9 . 2273–85 . 2001 . 11331592 . 125435 . 10.1093/emboj/20.9.2273 .

Notes and References

1. Girling R, Partridge JF, Bandara LR, Burden N, Totty NF, Hsuan JJ, La Thangue NB . A new component of the transcription factor DRTF1/E2F . Nature . 365 . 6445 . 468 . Nov 1993 . 8413592 . 10.1038/365468d0 . 1993Natur.365R.468G . free .
2. Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP . Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family . Genomics . 39 . 1 . 95–8 . Mar 1997 . 9027491 . 10.1006/geno.1996.4473 .
3. Web site: Entrez Gene: TFDP1 transcription factor Dp-1.
4. Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA . E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle . Proc. Natl. Acad. Sci. U.S.A. . 92 . 6 . 2403–7 . Mar 1995 . 7892279 . 42492 . 10.1073/pnas.92.6.2403. 1995PNAS...92.2403S . free .
5. Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K . A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer . Oncogene . 17 . 7 . 853–65 . Aug 1998 . 9780002 . 10.1038/sj.onc.1202163 . 23588950 .
6. Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA . In vivo association of E2F and DP family proteins . Mol. Cell. Biol. . 15 . 5 . 2536–46 . May 1995 . 7739537 . 230484 . 10.1128/mcb.15.5.2536.
7. Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E . Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation . Genes Dev. . 7 . 10 . 1850–61 . Oct 1993 . 8405995 . 10.1101/gad.7.10.1850. free .
8. Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R . E2F-5, a new E2F family member that interacts with p130 in vivo . Mol. Cell. Biol. . 15 . 6 . 3082–9 . Jun 1995 . 7760804 . 230539 . 10.1128/mcb.15.6.3082.
9. Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB . Functional interaction between DP-1 and p53 . Mol. Cell. Biol. . 16 . 10 . 5888–95 . Oct 1996 . 8816502 . 231590 . 10.1128/mcb.16.10.5888.