TFCP2 explained

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.[1] [2]

TFCP2 is also called Late SV40 factor (LSF) and it is induced by well-known oncogene AEG-1.[3] LSF also acts as an oncogene in hepatocellular carcinoma.[4] LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).[5]

Along with its main oncogene function in hepatocellular carcinoma (HCC), it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.[4] [6] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding with HCC DNA, which results in HCC cell death.[4] [6] [7]

Interactions

TFCP2 has been shown to interact with APBB1[8] and RNF2.[9]

Further reading

Notes and References

  1. Swendeman SL, Spielholz C, Jenkins NA, Gilbert DJ, Copeland NG, Sheffery M . Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2 . The Journal of Biological Chemistry . 269 . 15 . 11663–71 . Apr 1994 . 10.1016/S0021-9258(19)78176-9 . 8157699 . free .
  2. Web site: Entrez Gene: TFCP2 transcription factor CP2.
  3. Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D . Identification of genes conferring resistance to 5-fluorouracil . Proceedings of the National Academy of Sciences of the United States of America . 106 . 31 . 12938–43 . Aug 2009 . 19622726 . 2722317 . 10.1073/pnas.0901451106 . 2009PNAS..10612938Y . free .
  4. Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D . Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma . Proceedings of the National Academy of Sciences of the United States of America . 107 . 18 . 8357–62 . May 2010 . 20404171 . 2889542 . 10.1073/pnas.1000374107 . 2010PNAS..107.8357Y . free .
  5. Santhekadur PK, Gredler R, Chen D, Siddiq A, Shen XN, Das SK, Emdad L, Fisher PB, Sarkar D . Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9) . The Journal of Biological Chemistry . 287 . 5 . 3425–32 . Jan 2012 . 22167195 . 3270996 . 10.1074/jbc.M111.298976 . free .
  6. Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SC, Hansen U, Fisher PB, Sarkar D . 2012 . The transcription factor LSF: a novel oncogene for hepatocellular carcinoma . Am J Cancer Res . 2 . 3 . 269–285 . 22679558 . 3365805 .
  7. Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U . Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma . Proceedings of the National Academy of Sciences of the United States of America . 109 . 12 . 4503–8 . Mar 2012 . 22396589 . 3311344 . 10.1073/pnas.1121601109 . 2012PNAS..109.4503G . free .
  8. Zambrano N, Minopoli G, de Candia P, Russo T . The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1 . The Journal of Biological Chemistry . 273 . 32 . 20128–33 . Aug 1998 . 9685356 . 10.1074/jbc.273.32.20128 . free .
  9. Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM . Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors . Molecular and Cellular Biology . 22 . 6 . 1936–46 . Mar 2002 . 11865070 . 135618 . 10.1128/MCB.22.6.1936-1946.2002 .

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