TFAP4 explained

Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.^[1]

Function

Transcription factor AP4 is a member of the basic helix-loop-helix (bHLH) transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.

Further reading

• Hu YF . Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity . Genes Dev. . 4 . 10 . 1741–52 . 1991 . 2123466 . 10.1101/gad.4.10.1741 . vanc. Lüscher B . Admon A . 3 . Mermod . N . Tjian . R . free.
• Mermod N, Williams TJ, Tjian R . Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro . Nature . 332 . 6164 . 557–61 . 1988 . 2833704 . 10.1038/332557a0 . 1988Natur.332..557M . 4340282 .
• Richard Gaynor . Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB . Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function . J. Virol. . 68 . 11 . 7188–99 . 1994 . 7933101 . 10.1128/JVI.68.11.7188-7199.1994. 237158 .
• Lewis TB . Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24 . Genomics . 32 . 1 . 131–3 . 1996 . 8786101 . 10.1006/geno.1996.0088 . vanc. Wood S . Michaelis EK . 3 . Dupont . B.R. . Leach . R.J. .
• Petersenn S, Rasch AC, Heyens M, Schulte HM . Structure and regulation of the human growth hormone-releasing hormone receptor gene . Mol. Endocrinol. . 12 . 2 . 233–47 . 1998 . 9482665 . 10.1210/mend.12.2.0057 . free .
• King-Jones K, Korge G, Lehmann M . The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4 . J. Mol. Biol. . 291 . 1 . 71–82 . 1999 . 10438607 . 10.1006/jmbi.1999.2963 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . vanc. Jedrychowski M . Schwartz D . 3 . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Martin J . The sequence and analysis of duplication-rich human chromosome 16 . Nature . 432 . 7020 . 988–94 . 2005 . 15616553 . 10.1038/nature03187 . vanc. Han C . Gordon LA . 3 . Terry . Astrid . Prabhakar . Shyam . She . Xinwei . Xie . Gary . Hellsten . Uffe . Chan . Yee Man . 2004Natur.432..988M . 4362044 . free .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . vanc. Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . free .

Notes and References

1. Web site: Entrez Gene: TFAP4 transcription factor AP-4 (activating enhancer binding protein 4).