TESK2 explained

Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene.^{[1] [2]}

Function

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meiotic stages and/or early stages of spermiogenesis.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Toshima JY, Toshima J, Watanabe T, Mizuno K . Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1 . The Journal of Biological Chemistry . 276 . 46 . 43471–81 . November 2001 . 11555644 . 10.1074/jbc.M104620200 . free .
• Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K . Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells . The Journal of Biological Chemistry . 276 . 33 . 31449–58 . August 2001 . 11418599 . 10.1074/jbc.M102988200 . free .

Notes and References

1. Røsok O, Pedeutour F, Ree AH, Aasheim HC . Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis . Genomics . 61 . 1 . 44–54 . October 1999 . 10512679 . 10.1006/geno.1999.5922 .
2. Web site: Entrez Gene: TESK2 testis-specific kinase 2.