TESK1 explained

Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene.^{[1] [2]}

Function

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis.^[2]

Interactions

TESK1 has been shown to interact with YWHAB^[3] and SPRY4.^[4]

Further reading

• Toshima J, Tanaka T, Mizuno K . Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loop . J. Biol. Chem. . 274 . 17 . 12171–6 . 1999 . 10207045 . 10.1074/jbc.274.17.12171 . free .
• Røsok O, Pedeutour F, Ree AH, Aasheim HC . Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis . Genomics . 61 . 1 . 44–54 . 1999 . 10512679 . 10.1006/geno.1999.5922 .
• Toshima J, Toshima JY, Amano T, Yang N, Narumiya S, Mizuno K . Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation . Mol. Biol. Cell . 12 . 4 . 1131–45 . 2001 . 11294912 . 32292 . 10.1091/mbc.12.4.1131 .
• Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K . Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells . J. Biol. Chem. . 276 . 33 . 31449–58 . 2001 . 11418599 . 10.1074/jbc.M102988200 . free.
• Toshima JY, Toshima J, Watanabe T, Mizuno K . Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1 . J. Biol. Chem. . 276 . 46 . 43471–81 . 2001 . 11555644 . 10.1074/jbc.M104620200 . free .
• Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ . Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1 . Eur. J. Biochem. . 269 . 10 . 2546–56 . 2002 . 12027893 . 10.1046/j.1432-1033.2002.02921.x . free .
• LaLonde DP, Brown MC, Bouverat BP, Turner CE . Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin . J. Biol. Chem. . 280 . 22 . 21680–8 . 2005 . 15817463 . 10.1074/jbc.M500752200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Toshima J, Ohashi K, Okano I, Nunoue K, Kishioka M, Kuma K, Miyata T, Hirai M, Baba T, Mizuno K . Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells . J. Biol. Chem. . 270 . 52 . 31331–7 . December 29, 1995 . 8537404 . 10.1074/jbc.270.52.31331 . free .
2. Web site: Entrez Gene: TESK1 testis-specific kinase 1.
3. Toshima JY, Toshima J, Watanabe T, Mizuno K . Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1 . J. Biol. Chem. . 276 . 46 . 43471–81 . November 2001 . 11555644 . 10.1074/jbc.M104620200 . free .
4. Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ . Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1 . Eur. J. Biochem. . 269 . 10 . 2546–56 . May 2002 . 12027893 . 10.1046/j.1432-1033.2002.02921.x . free .