TEP1 explained

Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene.^{[1] [2]}

Function

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. It is also a minor vault protein.

Further reading

• Joly EC, Tremblay E, Tanguay RM, Wu Y, Bibor-Hardy V . TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix . Journal of Cell Science . 107 (Pt 10) . 10 . 2851–9 . October 1994 . 10.1242/jcs.107.10.2851 . 7876352 .
• Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO . A mammalian telomerase-associated protein . Science . 275 . 5302 . 973–7 . February 1997 . 9020079 . 10.1126/science.275.5302.973 . 21631570 .
• Harrington L, Zhou W, McPhail T, Oulton R, Yeung DS, Mar V, Bass MB, Robinson MO . Human telomerase contains evolutionarily conserved catalytic and structural subunits . Genes & Development . 11 . 23 . 3109–15 . December 1997 . 9389643 . 316744 . 10.1101/gad.11.23.3109 .
• Li H, Zhao L, Yang Z, Funder JW, Liu JP . Telomerase is controlled by protein kinase Calpha in human breast cancer cells . The Journal of Biological Chemistry . 273 . 50 . 33436–42 . December 1998 . 9837921 . 10.1074/jbc.273.50.33436 . free .
• Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH . Vaults and telomerase share a common subunit, TEP1 . The Journal of Biological Chemistry . 274 . 46 . 32712–7 . November 1999 . 10551828 . 10.1074/jbc.274.46.32712 . free .
• Li H, Cao Y, Berndt MC, Funder JW, Liu JP . Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro . Oncogene . 18 . 48 . 6785–94 . November 1999 . 10597287 . 10.1038/sj.onc.1203061 . free .
• Koyanagi Y, Kobayashi D, Yajima T, Asanuma K, Kimura T, Sato T, Kida T, Yagihashi A, Kameshima H, Watanabe N . Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells . Anticancer Research . 20 . 2A . 773–8 . 2000 . 10810353 .
• Beattie TL, Zhou W, Robinson MO, Harrington L . Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding . Molecular Biology of the Cell . 11 . 10 . 3329–40 . October 2000 . 11029039 . 14995 . 10.1091/mbc.11.10.3329 .
• Zhang RG, Zhang RP, Wang XW, Xie H . Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells . Cell Research . 12 . 1 . 55–62 . March 2002 . 11942411 . 10.1038/sj.cr.7290110 . free .
• Chang JT, Chen YL, Yang HT, Chen CY, Cheng AJ . Differential regulation of telomerase activity by six telomerase subunits . European Journal of Biochemistry . 269 . 14 . 3442–50 . July 2002 . 12135483 . 10.1046/j.1432-1033.2002.03025.x . free .
• Zhou JH, Zhang HM, Chen Q, Han DD, Pei F, Zhang LS, Yang DT . Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma . World Journal of Gastroenterology . 9 . 8 . 1808–14 . August 2003 . 12918126 . 10.3748/wjg.v9.i8.1808. 4611549 . free .
• Li C, Wu MY, Liang YR, Wu XY . Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma . World Journal of Gastroenterology . 9 . 11 . 2395–9 . November 2003 . 14606063 . 10.3748/wjg.v9.i11.2395. 4656508 . free .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . free .

Notes and References

1. Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F . Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases . Genomics . 46 . 1 . 46–50 . November 1997 . 9403057 . 10.1006/geno.1997.5005 .
2. Web site: Entrez Gene: TEP1 telomerase-associated protein 1.