| Country: | EUR |
| Type: | E |
| Route: | 80 |
| Length Km: | 6102 |
| Direction A: | West |
| Terminus A: |  Lisbon, Portugal |
| Direction B: | East |
| Terminus B: |  Gürbulak, Turkey |
| Countries: | Portugal Spain France Italy Croatia Montenegro Serbia Bulgaria Turkey |
European route E80, also known as the Trans-European Motorway or TEM, is an A-Class West-East European route, extending from Lisbon, Portugal to Gürbulak, Turkey, on the border with Iran. The road connects 10 countries and has a length of approximately . At its eastern end it joins end-on with Asian Highway AH1 which continues all the way to Tokyo, Japan.
Lisbon (start of concurrency with) - Torres Novas - Coimbra - Aveiro (end of concurrency with)
Aveiro - Viseu - Guarda - Vilar Formoso
Fuentes de Oñoro - Salamanca - Tordesillas - Burgos
Burgos (start of concurrency with)
Burgos - Miranda de Ebro - Vitoria-Gasteiz
Eibar (start of concurrency with) - Donostia/S. Sebastian - Irún
Hendaye - Bayonne (end of concurrency with)
Toulouse - Villefranche-de-Lauragais - Carcassonne - Narbonne
Narbonne (start of concurrency with) - Béziers - Montpellier - Nîmes (end of concurrency with)
Salon-de-Provence - Aix-en-Provence
Ventimiglia - Savona - Genoa
Genoa - La Spezia - Lucca - Rosignano Solvay
Rosignano Solvay - Grosseto - Tarquinia
Gap - Adriatic Sea
Dubrovnik (start of concurrency with) - Karasovići
Debeli Brijeg - Petrovac na Moru (start of concurrency with) - Sutomore (end of concurrency with)
Virpazar - Podgorica - Ribarevine
Ribarevine - Berane - Dračenovac
Bërnjak - Mitrovica - Pristina (end of concurrency with)
Prishtina - Trudë
Trudë - Merdar
Merdare - Prokuplje - Merošina (start of concurrency with)
Merošina - Trupale (end of concurrency with)
Chirpan - Dimitrovgrad - Svilengrad - Kapitan Andreevo
Edirne - Babaeski - Lüleburgaz - Çorlu - Silivri
Silivri - Istanbul - Gebze - Izmit - Adapazari - Hendek
Hendek - Düzce - Bolu - Gerede
Gerede - Ilgaz - Merzifon - Refahiye - Erzincan - Aşkale - Erzurum - Horasan - Ağrı - Doğubeyazıt - Gürbulak