Tektin-1 Explained
Tektin-1 is a protein that in humans is encoded by the TEKT1 gene.[1] [2]
Function
This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis.[1]
Further reading
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
- Rose JE, Behm FM, Drgon T, etal . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. . Mol. Med. . 16 . 7–8 . 247–53 . 2010. 20379614 . 10.2119/molmed.2009.00159 . 2896464.
- Newby PR, Pickles OJ, Mazumdar S, etal . Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. . Eur. J. Hum. Genet. . 18 . 9 . 1021–6 . 2010 . 20442750 . 10.1038/ejhg.2010.55 . 2987410.
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.
- Iguchi N, Tanaka H, Nakamura Y, etal . Cloning and characterization of the human tektin-t gene. . Mol. Hum. Reprod. . 8 . 6 . 525–30 . 2002 . 12029069 . 10.1093/molehr/8.6.525. free .
Notes and References
- Web site: Entrez Gene: tektin 1.
- Xu M, Zhou Z, Cheng C, Zhao W, Tang R, Huang Y, Wang W, Xu J, Zeng L, Xie Y, Mao Y . Cloning and characterization of a novel human TEKTIN1 gene . Int. J. Biochem. Cell Biol. . 33 . 12 . 1172–82 . December 2001 . 11606253 . 10.1016/S1357-2725(01)00089-9.
