TDRD7 explained

Tudor domain-containing protein 7 is a protein that in humans is encoded by the TDRD7 gene.^{[1] [2]}

In melanocytic cells TDRD7 gene expression may be regulated by MITF.^[3]

Gene polymorphism

Various single nucleotide polymorphisms (SNPs) of the TDRD7 gene have been identified and for some of them an association with lower susceptibility to age-related cataract was shown.^[4]

Interactions

TDRD7 has been shown to interact with TACC1.^[5]

Further reading

• Huda Zoghbi . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D . TACC1-chTOG-Aurora A protein complex in breast cancer . Oncogene . 22 . 50 . 8102–16 . 2003 . 14603251 . 10.1038/sj.onc.1206972 . 10536264 .
• Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH . Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells . Biochem. J. . 363 . Pt 1 . 195–200 . 2002 . 11903063 . 1222467 . 10.1042/0264-6021:3630195 .
• Yamochi T, Nishimoto I, Okuda T, Matsuoka M . ik3-1/Cables is associated with Trap and Pctaire2 . Biochem. Biophys. Res. Commun. . 286 . 5 . 1045–50 . 2001 . 11527406 . 10.1006/bbrc.2001.5493 .
• Hirose T, Kawabuchi M, Tamaru T, Okumura N, Nagai K, Okada M . Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain . Eur. J. Biochem. . 267 . 7 . 2113–21 . 2000 . 10727952 . 10.1046/j.1432-1327.2000.01218.x .

Notes and References

1. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . Dec 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
2. Web site: Entrez Gene: TDRD7 tudor domain containing 7.
3. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E . Novel MITF targets identified using a two-step DNA microarray strategy . Pigment Cell Melanoma Res . 21 . 6 . 665–76 . 2008 . 19067971 . 10.1111/j.1755-148X.2008.00505.x . 24698373 . free .
4. Zheng C, Wu M, He CY, An XJ, Sun M, Chen CL, Ye J . RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract . J. Int. Med. Res. . 42 . 1 . 153–63 . Feb 2014 . 24435515 . 10.1177/0300060513504702 . free .
5. Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D . TACC1-chTOG-Aurora A protein complex in breast cancer . Oncogene . 22 . 50 . 8102–16 . Nov 2003 . 14603251 . 10.1038/sj.onc.1206972 . 10536264 .