DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase explained

DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase
Ec Number:2.6.1.89

DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase (TylB, TDP-3-keto-6-deoxy-D-glucose 3-aminotransferase, TDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase, dTDP-3-keto-6-deoxy-D-glucose 3-aminotransferase, dTDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase) is an enzyme with systematic name dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose:2-oxoglutarate aminotransferase.[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons

dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate

This enzyme is a pyridoxal-phosphate protein.

Notes and References

  1. Melançon CE, Hong L, White JA, Liu YN, Liu HW . Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies . Biochemistry . 46 . 2 . 577–90 . January 2007 . 17209568 . 2515277 . 10.1021/bi061907y .

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