TCS-1205 explained

TCS 1205 is an organic chemical compound. It is a benzodiazepine site agonist selective for certain sub-units.

Pharmacology

TCS 1205 acts at the benzodiazepine binding site, it is selective for the a1 and a2 subunits of the GABAA receptor.[1] In vivo, it has anxiolytic effects but no sedative effects.[2] [3]

Chemistry

Despite acting at the benzodiazepine receptor, it does not contain the benzodiazepine structure, it could therefore be classed as a Nonbenzodiazepine.

Notes and References

  1. https://documents.tocris.com/pdfs/tocris_coa/3941_1_coa.pdf?1706728634
  2. Web site: TCS 1205 | CAS 355022-97-8 | AbMole BioScience | TCS 1205 Price .
  3. Taliani . Sabrina . Cosimelli . Barbara . Da Settimo . Federico . Marini . Anna Maria . La Motta . Concettina . Simorini . Francesca . Salerno . Silvia . Novellino . Ettore . Greco . Giovanni . Cosconati . Sandro . Marinelli . Luciana . Salvetti . Francesca . L’Abbate . Gianluca . Trasciatti . Silvia . Montali . Marina . Costa . Barbara . Martini . Claudia . Identification of Anxiolytic/Nonsedative Agents among Indol-3-ylglyoxylamides Acting as Functionally Selective Agonists at the γ-Aminobutyric Acid-A (GABA A) α 2 Benzodiazepine Receptor . Journal of Medicinal Chemistry . 25 June 2009 . 52 . 12 . 3723–3734 . 10.1021/jm9001154.

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